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Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64185, updated on 25-Apr-2024

Summary

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Official Symbol
Cap1provided by RGD
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 1provided by RGD
Primary source
RGD:620309
See related
Ensembl:ENSRNOG00000013492 AllianceGenome:RGD:620309
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mch1
Summary
Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in cAMP-mediated signaling; cell morphogenesis; and regulation of adenylate cyclase activity. Predicted to act upstream of or within actin cytoskeleton organization; ameboidal-type cell migration; and receptor-mediated endocytosis. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 734.1), Thymus (RPKM 537.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140427265..140507678, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135142108..135168885, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140559195..140585494, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene twinfilin actin-binding protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120102972 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene uncharacterized LOC100909490 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene MYCL proto-oncogene, bHLH transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation. Zhang H, et al. J Mol Neurosci, 2014 Dec. PMID 25060335
  2. CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury. Zhu X, et al. J Mol Histol, 2014 Jun. PMID 24272071
  3. Molecular cloning and characterization of a rat homolog of CAP, the adenylyl cyclase-associated protein from Saccharomyces cerevisiae. Zelicof A, et al. J Biol Chem, 1993 Jun 25. PMID 8514780
  4. CAP1 binds and activates adenylyl cyclase in mammalian cells. Zhang X, et al. Proc Natl Acad Sci U S A, 2021 Jun 15. PMID 34099549, Free PMC Article
  5. Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus. Rahmati M, et al. Gene, 2019 Apr 15. PMID 30682386

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAP1 binds and activates adenylyl cyclase in mammalian cells.
    Title: CAP1 binds and activates adenylyl cyclase in mammalian cells.
  2. Hippocampal Cap1 levels is sensitive to different exercise intensities.Highest corticosterone level and lactate production leads to reduction and induction of hippocampal Cap1.
    Title: Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus.
  3. Upregulation of CAP1 protein expression was associated with astrocyte proliferation after the trauma of the central nervous system.
    Title: The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation.
  4. CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.
    Title: CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.
  5. Cap1 regulates growth cone morphology through rearrangement of F-actin and thereby controls neurite outgrowth.
    Title: Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC108691

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ameboidal-type cell migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ameboidal-type cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylyl cyclase-associated protein 1
Names
CAP 1
CAP, adenylate cyclase-associated protein 1
adenylate cyclase associated protein 1
cyclase-associated protein homologue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022383.4 → NP_071778.2  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_071778.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A0A8L2QAE6, A6IS11
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    140427265..140507678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288342.1 → XP_063144412.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  2. XM_063288341.1 → XP_063144411.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  3. XM_039110702.2 → XP_038966630.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A0A8L2QAE6, A6IS11
    Related
    ENSRNOP00000081879.1
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  4. XM_063288346.1 → XP_063144416.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  5. XM_006238830.5 → XP_006238892.1  adenylyl cyclase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006238892.1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A0A8L2QAE6, A6IS11
    Related
    ENSRNOP00000018711.4
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  6. XM_006238832.5 → XP_006238894.1  adenylyl cyclase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006238894.1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A0A8L2QAE6, A6IS11
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  7. XM_006238831.5 → XP_006238893.1  adenylyl cyclase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006238893.1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A0A8L2QAE6, A6IS11
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  8. XM_063288340.1 → XP_063144410.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  9. XM_063288344.1 → XP_063144414.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  10. XM_063288345.1 → XP_063144415.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  11. XM_063288343.1 → XP_063144413.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A6IS11

  12. XM_039110703.2 → XP_038966631.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08163, Q5FVS8
    UniProtKB/TrEMBL
    A0A8L2QAE6, A6IS11
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08163.3 GenPept UniProtKB/Swiss-Prot:Q08163

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