vox ventral homeobox [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: voxprovided by ZNC
Official Full Name: ventral homeoboxprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010108-1
See related: Ensembl:ENSDARG00000099761 AllianceGenome:ZFIN:ZDB-GENE-010108-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vega1; zgc:136532
Summary: Enables protein heterodimerization activity and protein homodimerization activity. Acts upstream of or within dorsal/ventral pattern formation; regulation of endodermal cell fate specification; and regulation of mesodermal cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including cloacal chamber; embryonic structure; epidermis; hindbrain neural plate; and midbrain neural keel. Orthologous to human VENTX (VENT homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (50621929..50624154, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (50307020..50309245, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vent-family and their mRNAs are located in different areas of the tails of Zebrafish and Xenopus embryos
Title: The proteins of Vent-family and their mRNAs are located in different areas of the tails of Zebrafish and Xenopus embryos.
Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.
Title: The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2.
show that Pou5f1 binds to phylogenetically conserved Oct/Pou5f1 sites in the vox promoter, both in vivo and in vitro
Title: Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.
ved functions redundantly with vox/vega1 and vent/vega2 to restrict the organizer domain in zebrafish
Title: A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish.
vox plays a critical role in the establishment of the dorsoventral axis.
Title: Functional and hierarchical interactions among zebrafish vox/vent homeobox genes.
Regulation by Wnt8 restricts the size of the dorsal organizer in embryo.
Title: Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ventral homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131698.1 → NP_571773.1 ventral homeobox

See identical proteins and their annotated locations for NP_571773.1

Status: PROVISIONAL

Source sequence(s)

AF193837

UniProtKB/TrEMBL

Q9DG33

Related

ENSDARP00000131684.1, ENSDART00000167949.3

Conserved Domains (2) summary

COG5576
Location:75 → 187

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:121 → 173

Homeobox; Homeobox domain