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smtnb smoothelin b [ Danio rerio (zebrafish) ]

Gene ID: 664685, updated on 27-Mar-2024

Summary

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Official Symbol
smtnbprovided by ZNC
Official Full Name
smoothelin bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-2
See related
Ensembl:ENSDARG00000059442 AllianceGenome:ZFIN:ZDB-GENE-070912-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
smtn
Summary
Predicted to be involved in actin cytoskeleton organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in gut and swim bladder. Orthologous to human SMTN (smoothelin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See smtnb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (69292747..69414121, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (68520618..68642178, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase Jb Neighboring gene selenoprotein M Neighboring gene cyclin O Neighboring gene iron-sulfur cluster assembly 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatiotemporal expression of smooth muscle markers in developing zebrafish gut. Georgijevic S, et al. Dev Dyn, 2007 Jun. PMID 17474123
  2. Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis. Hachimi M, et al. Curr Biol, 2021 Feb 22. PMID 33275893, Free PMC Article
  3. miR-145 directs intestinal maturation in zebrafish. Zeng L, et al. Proc Natl Acad Sci U S A, 2009 Oct 20. PMID 19805048, Free PMC Article
  4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
smoothelin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    69292747..69414121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476690.1 → XP_021332365.1  smoothelin isoform X1

    UniProtKB/TrEMBL
    A0A8M9QEZ1
    Conserved Domains (2) summary
    pfam00307
    Location:792 → 900
    CH; Calponin homology (CH) domain
    pfam12510
    Location:553 → 602
    Smoothelin; Smoothelin cytoskeleton protein

  2. XM_021476693.1 → XP_021332368.1  smoothelin isoform X4

    UniProtKB/TrEMBL
    A0A8M9PZ83
    Conserved Domains (2) summary
    pfam00307
    Location:777 → 885
    CH; Calponin homology (CH) domain
    pfam12510
    Location:553 → 602
    Smoothelin; Smoothelin cytoskeleton protein

  3. XM_021476691.1 → XP_021332366.1  smoothelin isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q9X3
    Conserved Domains (3) summary
    pfam00307
    Location:788 → 896
    CH; Calponin homology (CH) domain
    pfam12510
    Location:553 → 602
    Smoothelin; Smoothelin cytoskeleton protein
    pfam14738
    Location:572 → 651
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1

  4. XM_021476692.1 → XP_021332367.1  smoothelin isoform X3

    UniProtKB/TrEMBL
    A0A8M9PLM4
    Conserved Domains (2) summary
    cd00014
    Location:795 → 895
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12510
    Location:553 → 602
    Smoothelin; Smoothelin cytoskeleton protein

  5. XM_021476694.1 → XP_021332369.1  smoothelin isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q505
    Conserved Domains (2) summary
    pfam00307
    Location:622 → 730
    CH; Calponin homology (CH) domain
    pfam12510
    Location:383 → 432
    Smoothelin; Smoothelin cytoskeleton protein

  6. XM_021476695.1 → XP_021332370.1  smoothelin isoform X6

    UniProtKB/TrEMBL
    A0A8M9QEZ3
    Conserved Domains (2) summary
    pfam00307
    Location:447 → 555
    CH; Calponin homology (CH) domain
    pfam12510
    Location:208 → 257
    Smoothelin; Smoothelin cytoskeleton protein

  7. XM_021476696.1 → XP_021332371.1  smoothelin isoform X7

    UniProtKB/TrEMBL
    A0A8M9Q9X6
    Related
    ENSDARP00000116548.2, ENSDART00000144570.4
    Conserved Domains (2) summary
    pfam00307
    Location:272 → 380
    CH; Calponin homology (CH) domain
    pfam12510
    Location:33 → 82
    Smoothelin; Smoothelin cytoskeleton protein
Nucleotide Protein Strain
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