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Dux double homeobox [ Mus musculus (house mouse) ]

Gene ID: 664783, updated on 12-May-2024

Summary

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Official Symbol
Duxprovided by MGI
Official Full Name
double homeoboxprovided by MGI
Primary source
MGI:MGI:3703875
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dux4; Duxbl; AW822073; EG664783
Annotation information
not in current annotation release
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Genomic context

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Location:
10 B4; 10

Bibliography

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Related articles in PubMed

  1. Functional study of distinct domains of Dux in improving mouse SCNT embryonic development†. Huang X, et al. Biol Reprod, 2021 Nov 15. PMID 34296246
  2. Dux facilitates post-implantation development, but is not essential for zygotic genome activation†. Bosnakovski D, et al. Biol Reprod, 2021 Jan 4. PMID 32997106, Free PMC Article
  3. Precise temporal regulation of Dux is important for embryo development. Guo M, et al. Cell Res, 2019 Nov. PMID 31591446, Free PMC Article
  4. DUX-family transcription factors regulate zygotic genome activation in placental mammals. De Iaco A, et al. Nat Genet, 2017 Jun. PMID 28459456, Free PMC Article
  5. High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice. Dandapat A, et al. PLoS One, 2016. PMID 26978271, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The homeobox transcription factor DUXBL controls exit from totipotency.
    Title: The homeobox transcription factor DUXBL controls exit from totipotency.
  2. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
    Title: Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.
  3. Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, gammaH2AX accumulation, and Bax/Bak-dependence.
    Title: Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence.
  4. Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.
    Title: Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.
  5. iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.
    Title: iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.
  6. RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy.
    Title: RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy.
  7. Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
    Title: Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.
  8. Functional study of distinct domains of Dux in improving mouse SCNT embryonic developmentdagger.
    Title: Functional study of distinct domains of Dux in improving mouse SCNT embryonic development†.
  9. Dux facilitates post-implantation development, but is not essential for zygotic genome activationdagger.
    Title: Dux facilitates post-implantation development, but is not essential for zygotic genome activation†.
  10. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
    Title: p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
double homeobox
Names
homeobox protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081954.1 → NP_001075423.1  double homeobox

    See identical proteins and their annotated locations for NP_001075423.1

    Status: PROVISIONAL

    Source sequence(s)
    AM398149
    UniProtKB/TrEMBL
    A1JVI6, A1JVI7, A1JVI8
    Conserved Domains (2) summary
    smart00389
    Location:112 → 162
    HOX; Homeodomain
    cd00086
    Location:19 → 73
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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