Trpm7 transient receptor potential cation channel, subfamily M, member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpm7provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily M, member 7provided by RGD
Primary source: RGD:620053
See related: Ensembl:ENSRNOG00000057806 AllianceGenome:RGD:620053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chak; Ltrpc7; LTrpC-7; Trp-plik
Summary: Enables calcium channel activity and protein kinase activity. Involved in several processes, including calcium ion transport; cellular magnesium ion homeostasis; and memory. Located in several cellular components, including neuronal cell body; synaptic vesicle membrane; and varicosity. Is integral component of membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 298.6), Thymus (RPKM 243.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (134499617..134588113, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114046258..114134799, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119258189..119347084, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCalpha-HuR axis in rheumatoid arthritis.
Title: TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis.
TRPM7 Mediates BSCB Disruption After Spinal Cord Injury by Regulating the mTOR/JMJD3 Axis in Rats.
Title: TRPM7 Mediates BSCB Disruption After Spinal Cord Injury by Regulating the mTOR/JMJD3 Axis in Rats.
Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
Title: Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.
Title: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.
Sevoflurane participates in the protection of rat renal ischemia-reperfusion injury by down-regulating the expression of TRPM7.
Title: Sevoflurane participates in the protection of rat renal ischemia-reperfusion injury by down-regulating the expression of TRPM7.
Transient receptor potential melastatin-7 in the rat dorsal root ganglion.
Title: Transient receptor potential melastatin-7 in the rat dorsal root ganglion.
Unraveling the Cardiac Effects Induced by Carvacrol in Spontaneously Hypertensive Rats: Involvement of Transient Receptor Potential Melastatin Subfamily 4 and 7 Channels.
Title: Unraveling the Cardiac Effects Induced by Carvacrol in Spontaneously Hypertensive Rats: Involvement of Transient Receptor Potential Melastatin Subfamily 4 and 7 Channels.
Transient Receptor Potential Melastatin 7 Promotes Vascular Adventitial Fibroblasts Phenotypic Transformation and Inflammatory Reaction Induced by Mechanical Stretching Stress via p38 MAPK/JNK Pathway.
Title: Transient Receptor Potential Melastatin 7 Promotes Vascular Adventitial Fibroblasts Phenotypic Transformation and Inflammatory Reaction Induced by Mechanical Stretching Stress via p38 MAPK/JNK Pathway.
Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light-Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro.
Title: Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light-Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro.
The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics.
Title: The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics.

Submit: New GeneRIF Correction See all GeneRIFs (58)

General gene information

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Markers

RH128920 (e-PCR)
- UniSTS:212228

RH133336 (e-PCR)
- UniSTS:216619

AU027696 (e-PCR)
- UniSTS:113054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables myosin binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium-dependent cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in intracellular magnesium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 7

Names: long transient receptor potential channel 7; transient receptor potential-phospholipase C-interacting kinase

NP_446157.2

EC 2.7.11.1

XP_038961765.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053705.2 → NP_446157.2 transient receptor potential cation channel subfamily M member 7

See identical proteins and their annotated locations for NP_446157.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

A7L642, Q925B3

UniProtKB/TrEMBL

A6HPZ2

Related

ENSRNOP00000084991.1, ENSRNOT00000112004.1

Conserved Domains (3) summary

smart00811
Location:1595 → 1813

Alpha_kinase; Alpha-kinase family

pfam00520
Location:877 → 1100

Ion_trans; Ion transport protein

pfam16519
Location:1198 → 1249

TRPM_tetra; Tetramerization domain of TRPM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

134499617..134588113 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105837.2 → XP_038961765.1 transient receptor potential cation channel subfamily M member 7 isoform X1

UniProtKB/Swiss-Prot

A7L642, Q925B3

UniProtKB/TrEMBL

A0A8I6AVX9

Related

ENSRNOP00000092648.1

Conserved Domains (4) summary

TIGR00870
Location:738 → 1188

trp; transient-receptor-potential calcium channel protein

cd16971
Location:1593 → 1831

Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7

pfam16519
Location:1210 → 1263

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:122 → 387

LSDAT_euk; SLOG in TRPM