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Gcn1 GCN1 activator of EIF2AK4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690632, updated on 30-Mar-2024

Summary

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Official Symbol
Gcn1provided by RGD
Official Full Name
GCN1 activator of EIF2AK4provided by RGD
Primary source
RGD:1593434
See related
Ensembl:ENSRNOG00000021871 AllianceGenome:RGD:1593434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcn1l1
Summary
Predicted to enable protein kinase binding activity; protein kinase regulator activity; and ribosome binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Predicted to be located in cytosol. Predicted to be part of polysome. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 174.2), Adrenal (RPKM 162.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46652273..46715119, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (40991512..41052661, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46728684..46789696, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BICD family like cargo adaptor 1 Neighboring gene RAB35, member RAS oncogene family Neighboring gene uncharacterized LOC120096002 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene paxillin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. Roffé M, et al. J Biol Chem, 2013 Apr 12. PMID 23447528, Free PMC Article
  2. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Cambiaghi TD, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333428
  3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables stalled ribosome sensor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GCN2-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
stalled ribosome sensor GCN1
Names
GCN1 eIF2 alpha kinase activator-like 1
GCN1 general control of amino-acid synthesis 1-like 1
GCN1, eIF2 alpha kinase activator homolog
eIF-2-alpha kinase activator GCN1
translational activator GCN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168664.1 → NP_001162135.1  stalled ribosome sensor GCN1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6G9H9, F1LRI5
    Related
    ENSRNOP00000001517.7, ENSRNOT00000001517.8
    Conserved Domains (4) summary
    cd00020
    Location:1498 → 1601
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam12074
    Location:355 → 705
    DUF3554; Domain of unknown function (DUF3554)
    pfam13646
    Location:1616 → 1721
    HEAT_2; HEAT repeats
    sd00044
    Location:1461 → 1485
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    46652273..46715119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089791.2 → XP_038945719.1  stalled ribosome sensor GCN1 isoform X2

    Conserved Domains (1) summary
    sd00044
    Location:1215 → 1249
    HEAT; HEAT repeat [structural motif]

  2. XM_039089790.2 → XP_038945718.1  stalled ribosome sensor GCN1 isoform X1

    Conserved Domains (1) summary
    sd00044
    Location:1215 → 1249
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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