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LRP6 LDL receptor related protein 6 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 695843, updated on 5-Mar-2024

Summary

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Official Symbol
LRP6provided by VGNC
Official Full Name
LDL receptor related protein 6provided by VGNC
Primary source
VGNC:VGNC:74446
Locus tag
EGK_03393
See related
Ensembl:ENSMMUG00000023317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See LRP6 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
23
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (13496433..13645349, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (12775989..12924967, complement)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114670790 Neighboring gene BCL2 like 14 Neighboring gene mortality factor 4-like protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene MANSC domain containing 1 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene AP-3 complex subunit sigma-1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 6
Names
low-density lipoprotein receptor-related protein 6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257719.1 → NP_001244648.1  low-density lipoprotein receptor-related protein 6 precursor

    See identical proteins and their annotated locations for NP_001244648.1

    Status: PROVISIONAL

    Source sequence(s)
    JU334495
    UniProtKB/TrEMBL
    A0A5F7ZGB8, A0A5K1UTM6, A0A8J8XIM2, F6Y514, G7N677
    Related
    ENSMMUP00000064636.1, ENSMMUT00000081160.1
    Conserved Domains (7) summary
    smart00135
    Location:483 → 524
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1326 → 1360
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:55 → 93
    NHL; NHL repeat [structural motif]
    cl18310
    Location:55 → 272
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00058
    Location:150 → 190
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:592 → 627
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:1069 → 1110
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    13496433..13645349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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