PKD2 polycystin 2, transient receptor potential cation channel [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PKD2provided by VGNC
Official Full Name: polycystin 2, transient receptor potential cation channelprovided by VGNC
Primary source: VGNC:VGNC:100262
See related: Ensembl:ENSMMUG00000008795
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	5	NC_041758.1 (86399578..86470892)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	5	NC_027897.1 (86364051..86435312)

Chromosome 5 - NC_041758.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-24101 (e-PCR)
- UniSTS:9043

SHGC-8591 (e-PCR)
- UniSTS:27987

D4S2796 (e-PCR)
- UniSTS:24407

G59384 (e-PCR)
- UniSTS:136549

SHGC-148257 (e-PCR)
- UniSTS:176285

SHGC-50276 (e-PCR)
- UniSTS:56245

G63630 (e-PCR)
- UniSTS:140741

SHGC-111600 (e-PCR)
- UniSTS:168425

STS-R48232 (e-PCR)
- UniSTS:12782

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables muscle alpha-actinin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated sodium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: polycystin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041758.1 Reference Mmul_10 Primary Assembly

Range

86399578..86470892

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028848611.1 → XP_028704444.1 polycystin-2 isoform X2

UniProtKB/TrEMBL

A0A5F7ZNH5, A0A5F8AFI1

Related

ENSMMUP00000076629.1, ENSMMUT00000102540.1

Conserved Domains (2) summary

pfam08016
Location:268 → 632

PKD_channel; Polycystin cation channel

cl08302
Location:677 → 723

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_001099242.4 → XP_001099242.2 polycystin-2 isoform X1

UniProtKB/TrEMBL

A0A5F7ZNH5, F7F220

Related

ENSMMUP00000011535.4, ENSMMUT00000012297.4

Conserved Domains (2) summary

pfam08016
Location:268 → 688

PKD_channel; Polycystin cation channel

cl08302
Location:733 → 779

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...