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Spata24 spermatogenesis associated 24 [ Mus musculus (house mouse) ]

Gene ID: 71242, updated on 12-May-2024

Summary

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Official Symbol
Spata24provided by MGI
Official Full Name
spermatogenesis associated 24provided by MGI
Primary source
MGI:MGI:1918492
See related
Ensembl:ENSMUSG00000024352 AllianceGenome:MGI:1918492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIPT; TIPT2; 2700012K08Rik; 4930583E11Rik; 5133400G04Rik
Summary
Enables DNA binding activity and identical protein binding activity. Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human SPATA24 (spermatogenesis associated 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 149.9) and liver E14 (RPKM 6.1) See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35789742..35795239, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35656689..35662186, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene marginal zone B and B1 cell-specific protein 1 Neighboring gene proline rich basic protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7578 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene STARR-seq mESC enhancer starr_44246 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1. Brancorsini S, et al. Cell Cycle, 2008 May 15. PMID 18418073
  2. TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation. Pitulescu ME, et al. BMC Biochem, 2009 Jun 10. PMID 19515240, Free PMC Article
  3. CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Sun J, et al. Biol Reprod, 2020 Aug 4. PMID 32588039, Free PMC Article
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1.
    Title: TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1.
  2. TIPT2 synergizes with geminin and TBP in the activation of TATA box-containing promoters.
    Title: TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 24
Names
TATA-binding protein-like factor-interacting protein
TLF-interacting protein
TRF2-interacting protein in testis
testis protein T6441 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027733.5 → NP_082009.3  spermatogenesis-associated protein 24 isoform 1

    See identical proteins and their annotated locations for NP_082009.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK016341, AW493519, BU961109
    Consensus CDS
    CCDS29147.1
    UniProtKB/TrEMBL
    A0A494B8X0
    Related
    ENSMUSP00000094324.3, ENSMUST00000096573.4
    Conserved Domains (1) summary
    pfam15175
    Location:25 → 128
    SPATA24; Spermatogenesis-associated protein 24

  2. NM_029485.2 → NP_083761.1  spermatogenesis-associated protein 24 isoform 2

    See identical proteins and their annotated locations for NP_083761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains additional coding exons at the 3' end compared to transcript variant 1, and encodes a longer isoform (2) with a different C-terminus compared to isoform 1.
    Source sequence(s)
    BC060950, BM569619, BU961109
    Consensus CDS
    CCDS29146.1
    UniProtKB/Swiss-Prot
    Q5MMR1, Q6P926, Q9D4P6
    Related
    ENSMUSP00000025209.5, ENSMUST00000025209.12
    Conserved Domains (2) summary
    pfam15175
    Location:25 → 190
    SPATA24; Spermatogenesis-associated protein 24
    cl09839
    Location:120 → 171
    Csx1_III-U; CRISPR/Cas system-associated protein Csx1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35789742..35795239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526248.5 → XP_006526311.1  spermatogenesis-associated protein 24 isoform X1

    UniProtKB/TrEMBL
    A0A494B928
    Related
    ENSMUSP00000157452.2, ENSMUST00000236539.2
    Conserved Domains (1) summary
    pfam15175
    Location:14 → 164
    SPATA24; Spermatogenesis-associated protein 24
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P926.1 GenPept UniProtKB/Swiss-Prot:Q6P926

Gene LinkOut

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