prl prolactin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prlprovided by ZNC
Official Full Name: prolactinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030513-1
See related: Ensembl:ENSDARG00000037946 AllianceGenome:ZFIN:ZDB-GENE-030513-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110500
Summary: Predicted to enable hormone activity. Acts upstream of or within ion homeostasis; multicellular organismal response to stress; and negative regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in adenohypophyseal placode; female organism; hypophysis; male organism; and peptide hormone secreting cell. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32341917..32345897)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32210203..32214183)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The primary function of zebrafish prl is osmoregulation via governing the uptake and homeostasis of Na(+), K(+) and Cl(-).
Title: The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models.
These studies in teleost models are contributing novel mechanistic insight into how prolactin participates in the development, function, and dysfunction of osmoregulatory systems across the vertebrate lineage.
Title: Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia.
Prolactin acts as a survival factor during zebrafish embryogenesis.
Title: Prolactin functions as a survival factor during zebrafish embryogenesis.
PRL knockdown embryos showed defects in gas bladder inflation, reduced head and eye size, shorter body length and fewer melanophores.
Title: The effects of the members of growth hormone family knockdown in zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin

Names: prl1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.