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relb v-rel avian reticuloendotheliosis viral oncogene homolog B [ Danio rerio (zebrafish) ]

Gene ID: 795414, updated on 19-Jun-2024

Summary

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Official Symbol
relbprovided by ZNC
Official Full Name
v-rel avian reticuloendotheliosis viral oncogene homolog Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9531
See related
Ensembl:ENSDARG00000086173 AllianceGenome:ZFIN:ZDB-GENE-030131-9531
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj85b02; wu:fj85b02
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including innate immune response; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See relb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (17100246..17125223)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (17164141..17188133)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking Neighboring gene v-mos Moloney murine sarcoma viral oncogene homolog Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene cullin 5a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Myocardial NF-κB activation is essential for zebrafish heart regeneration. Karra R, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26472034, Free PMC Article
  2. Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress. Zimmer TS, et al. Brain Pathol, 2021 Sep. PMID 33786950, Free PMC Article
  3. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. Marín-Juez R, et al. J Endocrinol, 2014 Aug. PMID 24904114
  4. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Wang C, et al. Fish Shellfish Immunol, 2018 Jan. PMID 29175471
  5. Gut bacteria Vibrio sp. and Aeromonas sp. trigger the expression levels of proinflammatory cytokine: First evidence from the germ-free zebrafish. Xin GY, et al. Fish Shellfish Immunol, 2020 Nov. PMID 32810528

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelium development IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor RelB
Names
v-rel reticuloendotheliosis viral oncogene homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    17100246..17125223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466348.1 → XP_021322023.1  transcription factor RelB isoform X1

    UniProtKB/TrEMBL
    A0A8M9P750
    Related
    ENSDARP00000128656.1, ENSDART00000154418.3
    Conserved Domains (2) summary
    cl08275
    Location:134 → 306
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    pfam16179
    Location:314 → 410
    RHD_dimer; Rel homology dimerisation domain

  2. XM_021466349.1 → XP_021322024.1  transcription factor RelB isoform X2

    UniProtKB/TrEMBL
    A0A8M9PC94
    Conserved Domains (2) summary
    cl08275
    Location:117 → 289
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    pfam16179
    Location:297 → 393
    RHD_dimer; Rel homology dimerisation domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394943.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    217117..242094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472925.1 → XP_021328600.1  transcription factor RelB isoform X1

    UniProtKB/TrEMBL
    A0A8M9P750
    Conserved Domains (2) summary
    cl08275
    Location:134 → 306
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    pfam16179
    Location:314 → 410
    RHD_dimer; Rel homology dimerisation domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395321.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    64269..89282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001335557.5 → XP_001335593.3  transcription factor RelB isoform X1

    UniProtKB/TrEMBL
    A0A8M1Q745
    Conserved Domains (2) summary
    cl08275
    Location:134 → 306
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    pfam16179
    Location:314 → 410
    RHD_dimer; Rel homology dimerisation domain
Nucleotide Protein Strain
Heading Accession and Version

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