adprs ADP-ribosylserine hydrolase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adprsprovided by ZNC
Official Full Name: ADP-ribosylserine hydrolaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-85
See related: Ensembl:ENSDARG00000019338 AllianceGenome:ZFIN:ZDB-GENE-040912-85
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adprhl2; fj36e06; zgc:92867; wu:fj36e06
Summary: Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, acting on glycosyl bonds; and magnesium ion binding activity. Predicted to be involved in DNA repair and peptidyl-serine ADP-deribosylation. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in site of DNA damage. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (31611863..31619274)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (31594900..31602322)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ADP-ribosylserine hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables O-acetyl-ADP-ribose deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chitooligosaccharide deacetylase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(ADP-ribose) glycohydrolase activity	IEA Inferred from Electronic Annotation more info
enables poly(ADP-ribose) glycohydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-ribosylhydrolase ARH3; poly(ADP-ribose) glycohydrolase ARH3

Names: ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 3; ADP-ribosylhydrolase like 2; O-acetyl-ADP-ribose deacetylase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase

NP_001004565.2

EC 3.2.1.143

XP_009291410.1

EC 3.2.1.143

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004565.2 → NP_001004565.2 ADP-ribosylhydrolase ARH3

See identical proteins and their annotated locations for NP_001004565.2

Status: VALIDATED

Source sequence(s)

EH450150, EH458878, EH475955, EH612280

UniProtKB/Swiss-Prot

A7MCF6, Q66HT8

Related

ENSDARP00000027022.9, ENSDART00000011706.10

Conserved Domains (1) summary

pfam03747
Location:19 → 326

ADP_ribosyl_GH; ADP-ribosylglycohydrolase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

31611863..31619274

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009293135.3 → XP_009291410.1 poly(ADP-ribose) glycohydrolase ARH3 isoform X1

UniProtKB/TrEMBL

A0A8M3ARH3

Conserved Domains (1) summary

cl00614
Location:2 → 183

ADP_ribosyl_GH; ADP-ribosylglycohydrolase