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grik1a glutamate receptor, ionotropic, kainate 1a [ Danio rerio (zebrafish) ]

Gene ID: 798001, updated on 11-Apr-2024

Summary

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Official Symbol
grik1aprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, kainate 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6502
See related
Ensembl:ENSDARG00000069139 AllianceGenome:ZFIN:ZDB-GENE-030131-6502
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grik1; fv36b03; wu:fv36b03
Summary
Predicted to enable glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within ion transport. Predicted to be located in membrane and synapse. Predicted to be integral component of membrane. Predicted to be active in postsynaptic membrane. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See grik1a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (25403022..25561852, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (25441309..25600136, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886714 Neighboring gene map3k7 C-terminal like Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 1 b Neighboring gene uncharacterized LOC103911747 Neighboring gene TIAM Rac1 associated GEF 1a Neighboring gene superoxide dismutase 1, soluble

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation. Sheets L. Sci Rep, 2017 Jan 23. PMID 28112265, Free PMC Article
  2. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. Levi L, et al. BMC Genomics, 2009 Mar 31. PMID 19335895, Free PMC Article
  3. Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). Messina A, et al. Eur J Neurosci, 2021 Jan. PMID 32692463
  4. The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Luo Q, et al. J Fish Biol, 2016 Apr. PMID 26992035
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kainate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor, ionotropic kainate 1; glutamate receptor ionotropic, kainate 1
Names
glutamate receptor, ionotropic, kainate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    25403022..25561852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305320.3 → XP_009303595.1  glutamate receptor ionotropic, kainate 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B391
    Related
    ENSDARP00000004703.9, ENSDART00000007778.10
    Conserved Domains (4) summary
    pfam00060
    Location:577 → 846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:57 → 398
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:37 → 432
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446 → 815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  2. XM_009305317.3 → XP_009303592.1  glutamate receptor ionotropic, kainate 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BCZ5
    Conserved Domains (4) summary
    pfam00060
    Location:577 → 846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:57 → 398
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:37 → 432
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446 → 815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  3. XM_001924003.7 → XP_001924038.3  glutamate receptor ionotropic, kainate 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M1QKZ5, E9QGN5
    Related
    ENSDARP00000118019.1, ENSDART00000147089.3
    Conserved Domains (4) summary
    pfam00060
    Location:562 → 831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:57 → 398
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:37 → 417
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431 → 800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  4. XM_009305319.3 → XP_009303594.1  glutamate receptor ionotropic, kainate 1 isoform X2

    See identical proteins and their annotated locations for XP_009303594.1

    UniProtKB/TrEMBL
    A0A8M3AWP9
    Conserved Domains (4) summary
    pfam00060
    Location:577 → 846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:57 → 398
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:37 → 432
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446 → 815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  5. XM_009305318.3 → XP_009303593.1  glutamate receptor ionotropic, kainate 1 isoform X2

    See identical proteins and their annotated locations for XP_009303593.1

    UniProtKB/TrEMBL
    A0A8M3AWP9
    Conserved Domains (4) summary
    pfam00060
    Location:577 → 846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:57 → 398
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:37 → 432
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446 → 815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version

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