nmba neuromedin Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nmbaprovided by ZNC
Official Full Name: neuromedin Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050419-3
See related: Ensembl:ENSDARG00000068144 AllianceGenome:ZFIN:ZDB-GENE-050419-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-77f17.8
Summary: Predicted to enable neuromedin B receptor binding activity and neuropeptide hormone activity. Predicted to be involved in positive regulation of hormone secretion. Predicted to act upstream of or within neuropeptide signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Is expressed in pancreatic D cell. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMB (neuromedin B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (26784965..26786347, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (26802587..26803603, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables neuromedin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuromedin Ba; neuromedin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082922.1 → NP_001076391.1 neuromedin Ba precursor

Status: PROVISIONAL

Source sequence(s)

AL935332

UniProtKB/TrEMBL

A0A8M1NC68, Q1MT60

Related

ENSDARP00000089132.4, ENSDART00000098361.5

Conserved Domains (1) summary

pfam02044
Location:47 → 60

Bombesin; Bombesin-like peptide

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

26784965..26786347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159302.4 → XP_005159359.1 neuromedin-B isoform X1

UniProtKB/TrEMBL

A0A8M2B675

Conserved Domains (1) summary

pfam02044
Location:47 → 60

Bombesin; Bombesin-like peptide