ahcyl1 adenosylhomocysteinase-like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ahcyl1provided by ZNC
Official Full Name: adenosylhomocysteinase-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-021206-7
See related: Ensembl:ENSDARG00000056331 AllianceGenome:ZFIN:ZDB-GENE-021206-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb586; wu:fj66f02
Summary: Predicted to enable adenosylhomocysteinase activity. Involved in embryonic morphogenesis. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be active in cytosol. Is expressed in several structures, including hatching gland; nervous system; pectoral fin musculature; polster; and pronephric duct. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (24971889..25011106, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (24952750..24991967, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
Title: Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
NOT enables adenosylhomocysteinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylhomocysteinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-adenosylhomocysteine hydrolase-like protein 1

Names: S-adenosylhomocysteine hydrolase-like 1

NP_958450.1

EC 3.13.2.1

XP_005167122.1

EC 3.13.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201293.1 → NP_958450.1 S-adenosylhomocysteine hydrolase-like protein 1

See identical proteins and their annotated locations for NP_958450.1

Status: PROVISIONAL

Source sequence(s)

BC054614

UniProtKB/TrEMBL

Q7T2B5

Related

ENSDARP00000073256.4, ENSDART00000078795.6

Conserved Domains (2) summary

PRK05476
Location:86 → 506

PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional

pfam05221
Location:86 → 511

AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

24971889..25011106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167065.3 → XP_005167122.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BEI8, A5PMG3

Related

ENSDARP00000073253.4, ENSDART00000078792.5

Conserved Domains (2) summary

PRK05476
Location:74 → 494

PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional

pfam05221
Location:74 → 499

AdoHcyase; S-adenosyl-L-homocysteine hydrolase