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nfya nuclear transcription factor Y, alpha [ Danio rerio (zebrafish) ]

Gene ID: 83915, updated on 27-Mar-2024

Summary

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Official Symbol
nfyaprovided by ZNC
Official Full Name
nuclear transcription factor Y, alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010501-1
See related
Ensembl:ENSDARG00000042004 AllianceGenome:ZFIN:ZDB-GENE-010501-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb16e03; tdsubc_2b6; wu:fb16e03; ik:tdsubc_2b6; xx:tdsubc_2b6
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of CCAAT-binding activity factor complex. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See nfya in Genome Data Viewer
Location:
chromosome: 11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (36254948..36279623, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (35993022..36017632, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-213o11.11 Neighboring gene caveolin 4a Neighboring gene sortilin 1a Neighboring gene proteasome 20S subunit alpha 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. NF-Y is critical for the proper growth of zebrafish embryonic heart and its cardiomyocyte proliferation. Chen J. Genesis, 2021 Feb. PMID 33417743
  2. Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish. Stanney W 3rd, et al. Dev Biol, 2020 Mar 15. PMID 31862379, Free PMC Article
  3. MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo. de Latouliere L, et al. Sci Rep, 2021 Jan 12. PMID 33436662, Free PMC Article
  4. Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development. Chen YH, et al. Bone, 2009 May. PMID 19442608
  5. Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Liu Q, et al. Reprod Toxicol, 2016 Oct. PMID 27544571

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NF-Y is critical for the proper growth of zebrafish embryonic heart and its cardiomyocyte proliferation.
    Title: NF-Y is critical for the proper growth of zebrafish embryonic heart and its cardiomyocyte proliferation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCAAT-binding factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear transcription factor Y subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082795.1 → NP_001076264.1  nuclear transcription factor Y subunit alpha

    See identical proteins and their annotated locations for NP_001076264.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133845
    UniProtKB/TrEMBL
    A0A8M1ND49, A3KNH7
    Related
    ENSDARP00000093838.3, ENSDART00000103064.5
    Conserved Domains (1) summary
    pfam02045
    Location:232 → 286
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    36254948..36279623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306191.3 → XP_009304466.1  nuclear transcription factor Y subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8M3B482, E9QGB7
    Related
    ENSDARP00000106116.3, ENSDART00000125616.4
    Conserved Domains (1) summary
    pfam02045
    Location:257 → 311
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  2. XM_009306192.3 → XP_009304467.1  nuclear transcription factor Y subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8M3AXW0
    Conserved Domains (1) summary
    pfam02045
    Location:245 → 299
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  3. XM_005172907.4 → XP_005172964.1  nuclear transcription factor Y subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKP2
    Conserved Domains (1) summary
    pfam02045
    Location:256 → 310
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  4. XM_009306188.3 → XP_009304463.1  nuclear transcription factor Y subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_009304463.1

    UniProtKB/TrEMBL
    A0A8M3B723
    Conserved Domains (1) summary
    pfam02045
    Location:257 → 311
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394825.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    215229..232006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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