Slc17a6 solute carrier family 17 member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc17a6provided by RGD
Official Full Name: solute carrier family 17 member 6provided by RGD
Primary source: RGD:620531
See related: Ensembl:ENSRNOG00000016147 AllianceGenome:RGD:620531
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnpi; Vglut2
Summary: Enables L-glutamate transmembrane transporter activity. Involved in hippocampus development; neural retina development; and neurotransmitter loading into synaptic vesicle. Located in cytoplasmic vesicle; excitatory synapse; and pericellular basket. Is integral component of synaptic vesicle membrane. Biomarker of transient cerebral ischemia. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 167.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (110348447..110388499)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (101212489..101252543)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (106980463..107038717)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging.
Title: Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging.
Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus.
Title: Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus.
Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular GABA transporter 1 (Vgat1) in the orofacial pain and temperature perception pathway under low estrogen conditions.
Title: Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular GABA transporter 1 (Vgat1) in the orofacial pain and temperature perception pathway under low estrogen conditions.
DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.
Title: DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.
Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons in the lateral reticular nucleus of the rat.
Title: Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons in the lateral reticular nucleus of the rat.
GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body.
Title: GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body.
Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy.
Title: Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy.
this study reports the cryo-electron microscopy structure of rat VGLUT2 at 3.8-angstrom resolution and propose structure-based mechanisms for substrate recognition and allosteric activation by low pH and chloride.
Title: Ion transport and regulation in a synaptic vesicle glutamate transporter.
The findingsof this study suggest that JC and JO motoneurons receive glutamatergic input primarily from VGLUT2-expressing intrinsic neurons (premotoneurons), and may be controlled differently by neurons in the trigeminal mesencephalic nucleus and by glutamatergic premotoneurons.
Title: Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons.
Study calculated the number and sizes of the labeled boutons and compared them between lateral/dentate nucleus (LN/DN), posterior interposed nucleus (PIN), anterior interposed nucleus (AIN), and medial nucleus (MN). The density of vGluT1+ boutons differs significantly within these nuclei. In contrast, the vGluT2+ bouton density is more similar between different nuclei.
Title: Quantitative Comparison Of Vesicular Glutamate Transporters in rat Deep Cerebellar Nuclei.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate uniporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamate uniporter activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate ion uniporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-glutamate import	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hyaloid vascular plexus regression	ISO Inferred from Sequence Orthology more info
involved_in hyaloid vascular plexus regression	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter loading into synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter loading into synaptic vesicle	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter loading into synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter loading into synaptic vesicle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse structure or activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in pericellular basket	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicular glutamate transporter 2

Names: differentation-associated Na-dependent inorganic phosphate cotransporter; differentiation-associated BNPI; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053427.1 → NP_445879.1 vesicular glutamate transporter 2

See identical proteins and their annotated locations for NP_445879.1

Status: PROVISIONAL

Source sequence(s)

AF271235

UniProtKB/Swiss-Prot

Q9JI12

UniProtKB/TrEMBL

A6JBH4, G3V851

Related

ENSRNOP00000022383.3, ENSRNOT00000022383.7

Conserved Domains (2) summary

cd06174
Location:75 → 498

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:70 → 511

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter