Rgs2 regulator of G-protein signaling 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs2provided by RGD
Official Full Name: regulator of G-protein signaling 2provided by RGD
Primary source: RGD:621665
See related: Ensembl:ENSRNOG00000003687 AllianceGenome:RGD:621665
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables beta-tubulin binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of glycine import across plasma membrane; and ovulation. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Biomarker of bladder disease (multiple); glomerulosclerosis; hypertension; liver cirrhosis; and opioid abuse. Orthologous to human RGS2 (regulator of G protein signaling 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 281.5), Brain (RPKM 239.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (58350063..58352666, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (55799749..55802354, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (60846458..60849061, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats.
Title: Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.
The protective effects of RGS2 in cardiac hypertrophy may derive at least in part from its ability to govern protein synthesis.
Title: The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes.
Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1
Title: Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1.
RGS2 functions on a daily basis to negatively modulate melatonin production
Title: RGS2 is a feedback inhibitor of melatonin production in the pineal gland.
Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2
Title: Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles.
Ischemic stress increases RGS2 expression and that this condition contributes to enhanced apoptosis in C6 cells and primary astrocytes.
Title: Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes.
S1P induces RGS2 and RGS16 mRNA expression but uses distinct S1P receptor subtypes and signalling pathways to regulate expression of these RGS proteins
Title: Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells.
Overexpression of Galpha(i2), PDE2a, and RGS2 down-regulates the beta-adrenergic signaling pathway, thus contributing to the pathogenesis of cirrhotic cardiomyopathy.
Title: An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats.
After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs2 , it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling.
Title: RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy.
changes in common to caveolin-1 expression and G protein signalling, through attenuation of Rgs2 and Rgs5, may contribute to hypertension through augmentation of vasoconstrictor pathways
Title: Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenylate cyclase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycine import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulator of G-protein signaling 2

Names: regulator of G-protein signaling protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053453.2 → NP_445905.1 regulator of G-protein signaling 2

See identical proteins and their annotated locations for NP_445905.1

Status: PROVISIONAL

Source sequence(s)

AF321837

UniProtKB/Swiss-Prot

Q9JHX0

UniProtKB/TrEMBL

A6ICP7

Related

ENSRNOP00000005156.3, ENSRNOT00000005156.7

Conserved Domains (1) summary

cd08709
Location:84 → 197

RGS_RGS2; Regulator of G protein signaling (RGS) domain found in the RGS2 protein