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cp ceruloplasmin [ Danio rerio (zebrafish) ]

Gene ID: 84702, updated on 26-May-2024

Summary

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Official Symbol
cpprovided by ZNC
Official Full Name
ceruloplasminprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010522-1
See related
Ensembl:ENSDARG00000010312 AllianceGenome:ZFIN:ZDB-GENE-010522-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fi23f10
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in iron ion homeostasis and iron ion transport. Predicted to act upstream of or within copper ion transport. Located in cytoplasm and nucleus. Is expressed in digestive system; female organism; liver and biliary system; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (38173974..38199757)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (38220827..38246610)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transmembrane 4 L six family member 4 Neighboring gene transmembrane 4 L six family member 18 Neighboring gene HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene si:ch211-284e20.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Imaging zebrafish neural circuitry from whole brain to synapse. Leung LC, et al. Front Neural Circuits, 2013. PMID 23630470, Free PMC Article
  2. Characterization of the ceruloplasmin gene and its potential role as an indirect marker for selection to Aeromonas hydrophila resistance in rohu, Labeo rohita. Sahoo PK, et al. Fish Shellfish Immunol, 2013 May. PMID 23481214
  3. Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders. Fish RJ, et al. Int J Mol Sci, 2021 Jan 11. PMID 33440782, Free PMC Article
  4. Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish. Wang Z, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30262142
  5. Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish. Zhang W, et al. iScience, 2021 Mar 19. PMID 33665561, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ferroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within copper ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ceruloplasmin
Names
cer
NP_571877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131802.1 → NP_571877.1  ceruloplasmin precursor

    See identical proteins and their annotated locations for NP_571877.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048037
    UniProtKB/TrEMBL
    Q7ZU12
    Related
    ENSDARP00000015293.8, ENSDART00000010537.10
    Conserved Domains (6) summary
    cd04222
    Location:23 → 205
    CuRO_1_ceruloplasmin; The first cupredoxin domain of Ceruloplasmin
    cd04225
    Location:745 → 915
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11012
    Location:927 → 1071
    CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:217 → 357
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:588 → 731
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:371 → 585
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    38173974..38199757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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