HTA1 histone H2A [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HTA1
Gene description: histone H2A
Primary source: SGD:S000002633
Locus tag: YDR225W
See related: AllianceGenome:SGD:S000002633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: H2A1; SPT11
Summary: Predicted to enable DNA binding activity. Involved in DNA repair; negative regulation of transcription by RNA polymerase II; and transfer RNA gene-mediated silencing. Part of replication fork protection complex. Orthologous to several human genes including H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (915530..915928)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

What makes a histone variant a variant: Changing H2A to become H2A.Z.
Title: What makes a histone variant a variant: Changing H2A to become H2A.Z.
Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B.
Title: Influence of sequence length and charged residues on Swc5 binding with histone H2A-H2B.
H2A.1 promotes high-fidelity homologous recombination, sister chromatid recombination (SCR), and break-induced replication whereas H2A.2 does not share these functions. Both decreased SCR and the increase in CAG expansions were due to the unique Thr126 residue in H2A.1 and hta1Delta or hta1-T126A mutants were epistatic to deletion of the Poldelta subunit Pol32, suggesting a role for H2A.1 in D-loop extension.
Title: Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126.
The article identifies proteins that directly bind the acidic patch in Saccharomyces cerevisiae: histone H2A binds to Paf1 complex subunit Rtf1 and FACT subunit Spt16.
Title: The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo.
This study not only demonstrates the applications of the versatile histone library, but also reveals many previously unknown functions of histone H2A and H2B.
Title: Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library.
Robust preinitiation complex-dependent H2A.Z eviction was observed at active and infrequently transcribed genes, indicating that constitutive H2A.Z turnover is a general phenomenon.
Title: Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex.
Dual function of Swc5 in SWR remodeling ATPase activation and histone H2A eviction has been reported.
Title: Dual function of Swc5 in SWR remodeling ATPase activation and histone H2A eviction.
Data indicate that copy number variation (CNV) is regulated by both promoter activity and acetylation of histone H3 lysine 56 (H3K56ac) and that H3K56ac is required for copper-resistance gene CUP1 CNV and efficient copper adaptation.
Title: Environmental change drives accelerated adaptation through stimulated copy number variation.
A Nap1 dimer provides an acidic binding surface and asymmetrically engages a single H2A-H2B heterodimer.
Title: Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.
Nap1 is essential for maintaining proper chromatin composition and modulating the exchange of H2A-H2B in vivo.
Title: Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	TAS Traceable Author Statement more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of replication fork protection complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H2A

NP_010511.3

Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo