TIF34 translation initiation factor eIF3 subunit i [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TIF34
Gene description: translation initiation factor eIF3 subunit i
Primary source: FungiDB:YMR146C
Locus tag: YMR146C
See related: SGD:S000004754; AllianceGenome:SGD:S000004754; VEuPathDB:YMR146C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables translation initiation factor activity. Involved in positive regulation of ATPase activity and translation reinitiation. Located in cytoplasmic stress granule. Part of eukaryotic translation initiation factor 3 complex and multi-eIF complex. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TIF34 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (557481..558524, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that mutations of eIF3 subunits, g/Tif35 and i/Tif34 diminish induction of GCN4 expression.
Title: The RNA recognition motif of eukaryotic translation initiation factor 3g (eIF3g) is required for resumption of scanning of posttermination ribosomes for reinitiation on GCN4 and together with eIF3i stimulates linear scanning.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation reinitiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info
part_of multi-eIF complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF3 subunit i

NP_013866.1

eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

557481..558524 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182648.1 → NP_013866.1 TPA: translation initiation factor eIF3 subunit i [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013866.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZMK5, D6VZW8, P40217

UniProtKB/TrEMBL

A0A6A5PTA5, B3LM34, B5VPS2, C7GQ86, C8ZF03, G2WKJ7, N1NYG2

Conserved Domains (2) summary

sd00039
Location:13 → 49

7WD40; WD40 repeat [structural motif]

cl29593
Location:6 → 319

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...