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CG42594 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674091, updated on 10-May-2024

Summary

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Official Symbol
CG42594provided by FlyBase
Primary source
FLYBASE:FBgn0260971
Locus tag
Dmel_CG42594
See related
AllianceGenome:FB:FBgn0260971
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15470; CG32770; CG32771; CG6952; Dmel\CG42594
Old locus tag
Dmel_CG15470; Dmel_CG32770; Dmel_CG32771
Summary
Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG42594 in Genome Data Viewer
Location:
4D2-4D5; 1-9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4840833..4906575)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4734866..4800608)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45516 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43495 Neighboring gene boilerman Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nonsense-mediated decay enables intron gain in Drosophila. Farlow A, et al. PLoS Genet, 2010 Jan 22. PMID 20107520, Free PMC Article
  2. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
  3. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
  4. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
  5. Operation of a homeostatic sleep switch. Pimentel D, et al. Nature, 2016 Aug 18. PMID 27487216, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42594-PA
CG42594-PC
CG42594-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4840833..4906575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297940.1 → NP_001284869.1  uncharacterized protein Dmel_CG42594, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJG8
    Conserved Domains (2) summary
    pfam00520
    Location:601 → 640
    Ion_trans; Ion transport protein
    pfam07885
    Location:599 → 656
    Ion_trans_2; Ion channel

  2. NM_001169196.3 → NP_001162667.1  uncharacterized protein Dmel_CG42594, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJG8
    Conserved Domains (2) summary
    pfam00520
    Location:601 → 640
    Ion_trans; Ion transport protein
    pfam07885
    Location:599 → 656
    Ion_trans_2; Ion channel

  3. NM_001169197.3 → NP_001162668.2  uncharacterized protein Dmel_CG42594, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162668.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJG7
    Conserved Domains (2) summary
    pfam00520
    Location:601 → 640
    Ion_trans; Ion transport protein
    pfam07885
    Location:599 → 656
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJG7 E1JJG7
E1JJG8 E1JJG8

Gene LinkOut

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