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Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89806, updated on 11-Apr-2024

Summary

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Official Symbol
Tie1provided by RGD
Official Full Name
tyrosine kinase with immunoglobulin-like and EGF-like domains 1provided by RGD
Primary source
RGD:621642
See related
Ensembl:ENSRNOG00000020173 AllianceGenome:RGD:621642
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in vasculogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 360.0), Heart (RPKM 236.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tie1 in Genome Data Viewer
Location:
5q36
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (137285408..137305047, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (132000013..132019658, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (137294544..137321116, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692460 Neighboring gene U6 spliceosomal RNA Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene uncharacterized LOC102554074 Neighboring gene transmembrane protein 258 like 2 Neighboring gene ribosomal protein S5, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery. Fujikawa K, et al. J Vasc Res, 1999 Jul-Aug. PMID 10474040
  2. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Zheng W, et al. Am J Physiol Heart Circ Physiol, 2004 Dec. PMID 15548727
  3. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. Shyu KG, et al. J Biomed Sci, 2004 Mar-Apr. PMID 14966366
  4. A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Loughna S, et al. Mol Cell, 2001 Jan. PMID 11172728
  5. TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Patan S. Microvasc Res, 1998 Jul. PMID 9683559

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ang2 and Tie2 expressions significantly increased both spatial and temporal patterns after myocardial infarction in the rat ventricular myocardium, while Ang1 and Tie1 receptor expression did not.
    Title: Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction.
  2. Mechanical stretch induces upregulation of the key tyrosine kinase receptors Flk-1, Tie-2, and Tie-1 in vascular endothelial cells
    Title: Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in branching involved in lymph vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within plasma membrane fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in vasculogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase receptor Tie-1
Names
tyrosine kinase receptor 1
NP_445997.1
XP_006238782.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053545.1 → NP_445997.1  tyrosine-protein kinase receptor Tie-1 precursor

    See identical proteins and their annotated locations for NP_445997.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169020
    UniProtKB/TrEMBL
    A6JZI8, B5DFD6
    Related
    ENSRNOP00000027414.5, ENSRNOT00000027414.8
    Conserved Domains (8) summary
    smart00219
    Location:838 → 1106
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:370 → 444
    IG_like; Immunoglobulin like
    cd00054
    Location:315 → 346
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:228 → 266
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:643 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05089
    Location:835 → 1131
    PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
    pfam00041
    Location:549 → 631
    fn3; Fibronectin type III domain
    pfam00047
    Location:130 → 211
    ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    137285408..137305047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238720.4 → XP_006238782.1  tyrosine-protein kinase receptor Tie-1 isoform X1

    UniProtKB/TrEMBL
    A6JZI8
    Conserved Domains (8) summary
    smart00219
    Location:836 → 1104
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:370 → 444
    IG_like; Immunoglobulin like
    cd00054
    Location:315 → 346
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:228 → 266
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:643 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05089
    Location:833 → 1129
    PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
    pfam00041
    Location:549 → 631
    fn3; Fibronectin type III domain
    pfam00047
    Location:130 → 211
    ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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