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    Acvrl1 activin A receptor, type II-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 11482, updated on 30-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Endoglin has a role in response to transforming growth factor beta1 and activation of Alk1 pathway

    Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway.
    Pece-Barbara N, Vera S, Kathirkamathamby K, Liebner S, Di Guglielmo GM, Dejana E, Wrana JL, Letarte M.

    01/21/2010
    ALK1 overexpression results in inhibition of bFGF-induced corneal neovascularization in vivo.

    Proteomic identification of activin receptor-like kinase-1 as a differentially expressed protein during hyaloid vascular system regression.
    Albè E, Escalona E, Rajagopal R, Javier JA, Chang JH, Azar DT.

    01/21/2010
    endoglin and Alk1 are necessary for the maintenance of distinct arterial-venous vascular beds

    Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor.
    Sorensen LK, Brooke BS, Li DY, Urness LD.

    01/21/2010
    ALK-1, an orphan receptor in the TGF-beta family, is a potential receptor for BMP-9

    Crystal structure of BMP-9 and functional interactions with pro-region and receptors.
    Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S.

    01/21/2010
    In differentiated endothelial stem cells ALK1 is implicated in mediating transforming beta 1 inhibition of sprouting angiogenesis.

    TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5.
    Mallet C, Vittet D, Feige JJ, Bailly S.

    01/21/2010
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