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    Lzts2 leucine zipper, putative tumor suppressor 2 [ Mus musculus (house mouse) ]

    Gene ID: 226154, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lzts2provided by MGI
    Official Full Name
    leucine zipper, putative tumor suppressor 2provided by MGI
    Primary source
    MGI:MGI:2385095
    See related
    Ensembl:ENSMUSG00000035342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAPSER1; BC014695; mKIAA1813
    Expression
    Broad expression in adrenal adult (RPKM 94.4), ovary adult (RPKM 63.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lzts2 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45003615..45015554)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45015176..45027115)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45089666..45101594)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3 Neighboring gene predicted gene, 35782 Neighboring gene Kazal-type serine peptidase inhibitor domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7094

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leucine zipper putative tumor suppressor 2
    Names
    protein LAPSER1
    putative tumor suppressor LAPSER1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130525.1NP_001123997.1  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_001123997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AA208269, AK129446, BX511791, CK021048
      Consensus CDS
      CCDS29855.1
      UniProtKB/Swiss-Prot
      Q91YU6
      Related
      ENSMUSP00000137571.2, ENSMUST00000179108.9
      Conserved Domains (2) summary
      pfam06818
      Location:441637
      Fez1
      pfam13851
      Location:404476
      GAS; Growth-arrest specific micro-tubule binding
    2. NM_001130526.1NP_001123998.1  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_001123998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AA208269, AK129446, BY726859, CK021048
      Consensus CDS
      CCDS29855.1
      UniProtKB/Swiss-Prot
      Q91YU6
      Related
      ENSMUSP00000136405.2, ENSMUST00000178087.3
      Conserved Domains (2) summary
      pfam06818
      Location:441637
      Fez1
      pfam13851
      Location:404476
      GAS; Growth-arrest specific micro-tubule binding
    3. NM_145503.2NP_663478.2  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_663478.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AA208269, AK129446, BY202542, CK021048
      Consensus CDS
      CCDS29855.1
      UniProtKB/Swiss-Prot
      Q91YU6
      Related
      ENSMUSP00000045478.7, ENSMUST00000039016.14
      Conserved Domains (2) summary
      pfam06818
      Location:441637
      Fez1
      pfam13851
      Location:404476
      GAS; Growth-arrest specific micro-tubule binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45003615..45015554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527004.4XP_006527067.1  leucine zipper putative tumor suppressor 2 isoform X1

      See identical proteins and their annotated locations for XP_006527067.1

      UniProtKB/Swiss-Prot
      Q91YU6
      Conserved Domains (2) summary
      pfam06818
      Location:441637
      Fez1
      pfam13851
      Location:404476
      GAS; Growth-arrest specific micro-tubule binding
    2. XM_030250898.2XP_030106758.1  leucine zipper putative tumor suppressor 2 isoform X1

      Conserved Domains (2) summary
      pfam06818
      Location:441637
      Fez1
      pfam13851
      Location:404476
      GAS; Growth-arrest specific micro-tubule binding
    3. XM_030250899.2XP_030106759.1  leucine zipper putative tumor suppressor 2 isoform X1

      Conserved Domains (2) summary
      pfam06818
      Location:441637
      Fez1
      pfam13851
      Location:404476
      GAS; Growth-arrest specific micro-tubule binding
    4. XM_006527005.5XP_006527068.1  leucine zipper putative tumor suppressor 2 isoform X3

      See identical proteins and their annotated locations for XP_006527068.1

      Conserved Domains (2) summary
      pfam06818
      Location:220416
      Fez1
      pfam13851
      Location:183255
      GAS; Growth-arrest specific micro-tubule binding
    5. XM_030250900.1XP_030106760.1  leucine zipper putative tumor suppressor 2 isoform X2

      Conserved Domains (2) summary
      pfam06818
      Location:304500
      Fez1
      pfam13851
      Location:267339
      GAS; Growth-arrest specific micro-tubule binding
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