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    Iws1 IWS1, SUPT6 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 73473, updated on 8-May-2024

    Summary

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    Official Symbol
    Iws1provided by MGI
    Official Full Name
    IWS1, SUPT6 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1920723
    See related
    Ensembl:ENSMUSG00000024384 AllianceGenome:MGI:1920723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3000008H23; 1700069O15Rik
    Summary
    Predicted to be involved in several processes, including poly(A)+ mRNA export from nucleus; regulation of histone modification; and regulation of mRNA export from nucleus. Predicted to act upstream of or within RNA splicing; mRNA processing; and mRNA transport. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and nervous system. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.3), whole brain E14.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B1; 18 17.92 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32200377..32237384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32067326..32104331)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene myosin VIIB Neighboring gene predicted gene 16344 Neighboring gene STARR-seq mESC enhancer starr_44153 Neighboring gene predicted gene, 35010 Neighboring gene protein C Neighboring gene eukaryotic translation initiation factor pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic ablation of interacting with Spt6 (Iws1) causes early embryonic lethality. Orlacchio A, et al. PLoS One, 2018. PMID 30208029, Free PMC Article
    2. Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation. Oqani RK, et al. Sci Rep, 2019 Mar 7. PMID 30846735, Free PMC Article
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
      Title: Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein IWS1 homolog
    Names
    IWS1 homolog
    IWS1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173441.4 → NP_775617.1  protein IWS1 homolog

      See identical proteins and their annotated locations for NP_775617.1

      Status: VALIDATED

      Source sequence(s)
      AC127347
      Consensus CDS
      CCDS29115.1
      UniProtKB/Swiss-Prot
      Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q8C1D8, Q9D9H4
      Related
      ENSMUSP00000025243.4, ENSMUST00000025243.5
      Conserved Domains (2) summary
      PHA02664
      Location:206 → 317
      PHA02664; hypothetical protein; Provisional
      cl00146
      Location:475 → 739
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32200377..32237384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526292.5 → XP_006526355.1  protein IWS1 homolog isoform X2

      Conserved Domains (2) summary
      COG5271
      Location:3 → 464
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl00146
      Location:474 → 738
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    2. XM_006526291.5 → XP_006526354.1  protein IWS1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A1D5RLV0
      Related
      ENSMUSP00000148514.2, ENSMUST00000212675.2
      Conserved Domains (2) summary
      COG5271
      Location:18 → 462
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl00146
      Location:475 → 724
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RNA

    1. XR_386017.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1D8.1 GenPept UniProtKB/Swiss-Prot:Q8C1D8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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