NOB1 NIN1 (RPN12) binding protein 1 homolog [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOB1provided by HGNC
Official Full Name: NIN1 (RPN12) binding protein 1 homologprovided by HGNC
Primary source: HGNC:HGNC:29540
See related: Ensembl:ENSG00000141101 MIM:613586; AllianceGenome:HGNC:29540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ART-4; NOB1P; MST158; MSTP158; PSMD8BP1
Summary: In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]
Expression: Ubiquitous expression in ovary (RPKM 29.6), thyroid (RPKM 20.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q22.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (69741871..69754926, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (75544399..75557460, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (69775774..69788829, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA FEZF1-AS1 aggravates cell proliferation and migration in glioblastoma.
Title: LncRNA FEZF1-AS1 aggravates cell proliferation and migration in glioblastoma.
Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
Title: Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
MicroRNA-612 inhibits cervical cancer progression by targeting NOB1.
Title: MicroRNA-612 inhibits cervical cancer progression by targeting NOB1.
MiR-363 suppresses cell migration, invasion, and epithelial-mesenchymal transition of osteosarcoma by binding to NOB1.
Title: MiR-363 suppresses cell migration, invasion, and epithelial-mesenchymal transition of osteosarcoma by binding to NOB1.
MicroRNA-139-3p suppresses growth and metastasis of glioblastoma via inhibition of NIN1/RPNI2 binding protein 1 homolog.
Title: MicroRNA-139-3p suppresses growth and metastasis of glioblastoma via inhibition of NIN1/RPNI2 binding protein 1 homolog.
NOB1: A Potential Biomarker or Target in Cancer.
Title: NOB1: A Potential Biomarker or Target in Cancer.
NOB1 was correlated with clinical outcomes and prognosis of gastric cancer patients and was an independent risk factor for 5-year mortality of GC patients.
Title: NOB1 Gene as a Potential Biomarker in Clinical Outcomes and Prognosis of Patients with Gastric Cancer.
A detailed characterization of Nob1 organization and its interaction with Pno1.
Title: Domain definition and interaction mapping for the endonuclease complex hNob1/hPno1.
These results suggested that RIOK2 and NOB1 may be potential targets in the treatment of Non-small cell lung cancer (NSCLC), and miR145 may be considered a therapeutic inhibitor of both genes.
Title: miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1.
our results indicate that miR-330-5p inhibits non-small-cell lung cancer (NSCLC) cell growth through downregulation of NOB1 expression. Our study suggests that miR-330-5p may serve as a potential therapeutic target for the treatment of NSCLC
Title: Inhibition of NOB1 by microRNA-330-5p overexpression represses cell growth of non-small cell lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45900 (e-PCR)
- UniSTS:38935

DXS9791 (e-PCR)
- UniSTS:9273

SHGC-60732 (e-PCR)
- UniSTS:60522

DXS7556 (e-PCR)
- UniSTS:26513

RH18146 (e-PCR)
- UniSTS:209598

D16S2647 (e-PCR)
- UniSTS:152254

A005R12 (e-PCR)
- UniSTS:5864

RH66628 (e-PCR)
- UniSTS:33018

RH65148 (e-PCR)
- UniSTS:2047

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA endonuclease activity	EXP Inferred from Experiment more info	PubMed
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	TAS Traceable Author Statement more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of preribosome, small subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein NOB1

Names: NIN1/PSMD8 binding protein 1 homolog; PSMD8 binding protein 1; adenocarcinoma antigen recognized by T lymphocytes 4; nin one binding protein; phosphorylation regulatory protein HP-10; protein ART-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014062.3 → NP_054781.1 RNA-binding protein NOB1

See identical proteins and their annotated locations for NP_054781.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AB026125

Consensus CDS

CCDS10884.1

UniProtKB/Swiss-Prot

Q7L6B7, Q7M4M4, Q7Z4B5, Q9NWB0, Q9ULX3

UniProtKB/TrEMBL

B2RAR2

Related

ENSP00000268802.5, ENST00000268802.10

Conserved Domains (3) summary

cd09876
Location:7 → 109

PIN_Nob1-like; VapC-like PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs

pfam08772
Location:260 → 332

NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

pfam15017
Location:152 → 212

WRNPLPNID; Putative WW-binding domain and destruction box

RNA

NR_074074.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC000050, BG386829, BM793847, DA004856, DB048531