FIGNL1 fidgetin like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FIGNL1provided by HGNC
Official Full Name: fidgetin like 1provided by HGNC
Primary source: HGNC:HGNC:13286
See related: Ensembl:ENSG00000132436 MIM:615383; AllianceGenome:HGNC:13286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]
Expression: Ubiquitous expression in lymph node (RPKM 1.9), appendix (RPKM 1.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p12.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (50444133..50450350, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (50605348..50611565, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (50511831..50518048, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.
Title: FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.
FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer.
Title: FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer.
FIGNL1 promotes nonsmall cell lung cancer cell proliferation.
Title: FIGNL1 promotes non‑small cell lung cancer cell proliferation.
The results identify Fignl1 as a key dynein regulator required for motor circuit wiring.
Title: FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation.
SWSAP1 protects RAD51 filaments by antagonizing the anti-recombinase, FIGNL1.
Title: Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase.
FIGL-1 is a new centrosomal protein and inhibits ciliogenesis.
Title: Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.
Further research assessing the functions and mechanisms of FIGNL1, and other homologous recombination pathway genes may disclose unique pathological characteristics of SCLC, and help identify potential therapeutic targets and biomarkers
Title: FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide.
RAD51-binding protein fidgetin-like 1 (FIGNL1) is identified; FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of FIGNL1 show defective homologous recombination repair.
Title: FIGNL1-containing protein complex is required for efficient homologous recombination repair.
Observational study of gene-disease association. (HuGE Navigator)
Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103568 (e-PCR)
- UniSTS:97893

D7S1606 (e-PCR)
- UniSTS:59831

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule severing ATPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in male meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fidgetin-like protein 1

NP_001036227.1

EC 3.6.4.-

NP_001274421.1

EC 3.6.4.-

NP_001274422.1

EC 3.6.4.-

NP_001274423.1

EC 3.6.4.-

NP_001274424.1

EC 3.6.4.-

NP_001274425.1

EC 3.6.4.-

NP_001333487.1

EC 3.6.4.-

NP_001333488.1

EC 3.6.4.-

NP_001333489.1

EC 3.6.4.-

NP_001333490.1

EC 3.6.4.-

NP_001333491.1

EC 3.6.4.-

NP_001333492.1

EC 3.6.4.-

NP_001333493.1

EC 3.6.4.-

NP_001333494.1

EC 3.6.4.-

NP_071399.2

EC 3.6.4.-

XP_011513772.1

EC 3.6.4.-

XP_016867990.1

EC 3.6.4.-

XP_024302631.1

EC 3.6.4.-

XP_024302632.1

EC 3.6.4.-

XP_024302633.1

EC 3.6.4.-

XP_047276649.1

EC 3.6.4.-

XP_054214752.1

EC 3.6.4.-

XP_054214753.1

EC 3.6.4.-

XP_054214754.1

EC 3.6.4.-

XP_054214755.1

EC 3.6.4.-

XP_054214756.1

EC 3.6.4.-

XP_054214757.1

EC 3.6.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051949.1 RefSeqGene

Range

5057..11274

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042762.5 → NP_001036227.1 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001036227.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Related

ENSP00000349356.4, ENST00000356889.8

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001287492.4 → NP_001274421.1 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001274421.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longer isoform (1). Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Related

ENSP00000399997.1, ENST00000433017.6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001287493.3 → NP_001274422.1 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001274422.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Related

ENSP00000483543.1, ENST00000615084.4

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001287494.4 → NP_001274423.1 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001274423.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001287495.3 → NP_001274424.1 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001274424.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Related

ENSP00000483126.1, ENST00000617389.4

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001287496.4 → NP_001274425.1 fidgetin-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001274425.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and includes additional splice sites in the 5' coding region resulting in translation initiation from a downstream start codon, compared to variant 3. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Variants 7-9 encode the same isoform (2).

Source sequence(s)

AC018705

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (3) summary

smart00382
Location:322 → 458

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:326 → 456

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:520 → 560

Vps4_C; Vps4 C terminal oligomerization domain
NM_001346558.3 → NP_001333487.1 fidgetin-like protein 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and includes additional splice sites in the 5' coding region resulting in translation initiation from a downstream start codon, compared to variant 3. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Variants 7-9 encode the same isoform (2).

Source sequence(s)

AC018705

UniProtKB/TrEMBL

B3KNH6
NM_001346559.3 → NP_001333488.1 fidgetin-like protein 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and includes additional splice sites in the 5' coding region resulting in translation initiation from a downstream start codon, compared to variant 3. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1. Variants 7-9 encode the same isoform (2).

Source sequence(s)

AC018705

UniProtKB/TrEMBL

B3KNH6
NM_001346560.3 → NP_001333489.1 fidgetin-like protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001346561.3 → NP_001333490.1 fidgetin-like protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001346562.3 → NP_001333491.1 fidgetin-like protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001346563.3 → NP_001333492.1 fidgetin-like protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001346564.3 → NP_001333493.1 fidgetin-like protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_001346565.3 → NP_001333494.1 fidgetin-like protein 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
NM_022116.7 → NP_071399.2 fidgetin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_071399.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-6 and 10-15 encode the same isoform (1).

Source sequence(s)

AC018705

Consensus CDS

CCDS5510.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Related

ENSP00000378924.2, ENST00000395556.6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

50444133..50450350 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446865.2 → XP_024302633.1 fidgetin-like protein 1 isoform X1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_024446863.2 → XP_024302631.1 fidgetin-like protein 1 isoform X1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_024446864.2 → XP_024302632.1 fidgetin-like protein 1 isoform X1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_011515470.4 → XP_011513772.1 fidgetin-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011513772.1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_047420693.1 → XP_047276649.1 fidgetin-like protein 1 isoform X1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

Related

ENSP00000410811.1, ENST00000419119.1
XM_017012501.2 → XP_016867990.1 fidgetin-like protein 1 isoform X1

UniProtKB/Swiss-Prot

D3DVM6, Q6PIW4, Q86V18, Q8ND59, Q9H8P1, Q9H917

UniProtKB/TrEMBL

B3KNH6

Conserved Domains (1) summary

COG0464
Location:374 → 668

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]