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    Loxl4 lysyl oxidase-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 67573, updated on 8-May-2024

    Summary

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    Official Symbol
    Loxl4provided by MGI
    Official Full Name
    lysyl oxidase-like 4provided by MGI
    Primary source
    MGI:MGI:1914823
    See related
    Ensembl:ENSMUSG00000025185 AllianceGenome:MGI:1914823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Loxc; 4833426I20Rik
    Summary
    Enables protein-lysine 6-oxidase activity. Predicted to be involved in collagen fibril organization and peptidyl-lysine oxidation. Located in extracellular region. Is expressed in several structures, including gut; male reproductive gland or organ; otic capsule; skeleton; and trachea. Orthologous to human LOXL4 (lysyl oxidase like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 3.3), bladder adult (RPKM 3.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Loxl4 in Genome Data Viewer
    Location:
    19 C3; 19 36.56 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42580718..42601326, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42592279..42612806, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7660 Neighboring gene predicted gene, 41851 Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene STARR-seq mESC enhancer starr_46188 Neighboring gene predicted gene, 25216 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 2 Neighboring gene predicted gene, 19437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer. Choi SK, et al. Oncotarget, 2017 Feb 14. PMID 28060764, Free PMC Article
    2. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. Li H, et al. Genes (Basel), 2021 Mar 31. PMID 33807332, Free PMC Article
    3. Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. Ito H, et al. J Biol Chem, 2001 Jun 29. PMID 11292829
    4. Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. Pischon N, et al. Calcif Tissue Int, 2009 Aug. PMID 19458888, Free PMC Article
    5. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. Goodwin AF, et al. J Dent Res, 2020 Nov. PMID 32623954, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
      Title: LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
    2. These results demonstrate that weak LOXL4 expression leads to remodeling of the extracellular matrix through induction of collagen synthesis, deposition, and structural changes.
      Title: LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine 6-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine 6-oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine 6-oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysyl oxidase homolog 4
    Names
    lysyl oxidase-like protein 4
    lysyl oxidase-related protein C
    NP_001157783.1
    NP_444313.3
    XP_036017562.1
    XP_036017563.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164311.1 → NP_001157783.1  lysyl oxidase homolog 4 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124552, AK014331, BC053925, BY145829
      Consensus CDS
      CCDS50441.1
      UniProtKB/TrEMBL
      E9Q600, Q6NV59
      Related
      ENSMUSP00000125803.2, ENSMUST00000164786.8
      Conserved Domains (3) summary
      smart00202
      Location:33 → 133
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:42 → 133
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:535 → 730
      Lysyl_oxidase; Lysyl oxidase

    2. NM_053083.3 → NP_444313.3  lysyl oxidase homolog 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_444313.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC124552, AK014331, BC053925, BY145829
      Consensus CDS
      CCDS29830.1
      UniProtKB/Swiss-Prot
      E9PXI3, Q924C6
      UniProtKB/TrEMBL
      Q6NV59
      Related
      ENSMUSP00000026190.8, ENSMUST00000026190.14
      Conserved Domains (3) summary
      smart00202
      Location:33 → 133
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:42 → 133
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:534 → 729
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      42580718..42601326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161669.1 → XP_036017562.1  lysyl oxidase homolog 4 isoform X1

      UniProtKB/TrEMBL
      Q6NV59
      Conserved Domains (2) summary
      smart00202
      Location:46 → 146
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:549 → 747
      Lysyl_oxidase; Lysyl oxidase

    2. XM_036161670.1 → XP_036017563.1  lysyl oxidase homolog 4 isoform X2

      UniProtKB/TrEMBL
      Q6NV59
      Conserved Domains (2) summary
      smart00202
      Location:46 → 146
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:548 → 746
      Lysyl_oxidase; Lysyl oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924C6.2 GenPept UniProtKB/Swiss-Prot:Q924C6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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