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    Pyroxd2 pyridine nucleotide-disulphide oxidoreductase domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 74580, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pyroxd2provided by MGI
    Official Full Name
    pyridine nucleotide-disulphide oxidoreductase domain 2provided by MGI
    Primary source
    MGI:MGI:1921830
    See related
    Ensembl:ENSMUSG00000060224 AllianceGenome:MGI:1921830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3830409H07Rik; 4833409A17Rik
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 27.6), adrenal adult (RPKM 17.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pyroxd2 in Genome Data Viewer
    Location:
    19 C3; 19 36.56 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42714296..42741261, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42725857..42752823, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46188 Neighboring gene lysyl oxidase-like 4 Neighboring gene predicted gene, 25216 Neighboring gene predicted gene, 19437 Neighboring gene predicted gene 16244 Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 Neighboring gene heparanase 2 Neighboring gene STARR-seq mESC enhancer starr_46190 Neighboring gene STARR-seq mESC enhancer starr_46192 Neighboring gene STARR-seq mESC enhancer starr_46193 Neighboring gene high mobility group box 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. Wang S, et al. PLoS Genet, 2006 Feb. PMID 16462940, Free PMC Article
    2. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029011.2 → NP_083287.2  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

      See identical proteins and their annotated locations for NP_083287.2

      Status: VALIDATED

      Source sequence(s)
      AK038414, AK160239, CB573340, CX218741
      Consensus CDS
      CCDS37991.1
      UniProtKB/Swiss-Prot
      E9QPD2, Q3U4I7, Q8CAN2, Q9D630
      UniProtKB/TrEMBL
      A0A494BA58
      Related
      ENSMUSP00000075825.4, ENSMUST00000076505.4
      Conserved Domains (2) summary
      COG1233
      Location:33 → 580
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:35 → 578
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      42714296..42741261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161713.1 → XP_036017606.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A494BA58
      Conserved Domains (1) summary
      COG1233
      Location:33 → 632
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

    2. XM_036161714.1 → XP_036017607.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A494BA58
      Conserved Domains (1) summary
      COG1233
      Location:33 → 629
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

    3. XM_011247383.4 → XP_011245685.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A494BA58
      Conserved Domains (1) summary
      COG1233
      Location:33 → 583
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

    RNA

    1. XR_003952824.2 RNA Sequence

    2. XR_004940178.1 RNA Sequence

    3. XR_877691.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U4I7.3 GenPept UniProtKB/Swiss-Prot:Q3U4I7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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