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    EWSAT1 Ewing sarcoma associated transcript 1 [ Homo sapiens (human) ]

    Gene ID: 283673, updated on 10-Oct-2023

    Summary

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    Official Symbol
    EWSAT1provided by HGNC
    Official Full Name
    Ewing sarcoma associated transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:26596
    See related
    Ensembl:ENSG00000212766 MIM:616492; AllianceGenome:HGNC:26596
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM84; LINC00277; NCRNA00277
    Expression
    Biased expression in testis (RPKM 2.1), kidney (RPKM 0.6) and 4 other tissues See more
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    Genomic context

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    See EWSAT1 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69080850..69095824)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66903394..66918357)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69373190..69388164)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NADPH oxidase 5 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69318396-69318896 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:69328421-69329620 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69341256-69341437 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:69352321-69352820 Neighboring gene uncharacterized LOC124903515 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69378684-69379278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69382031-69382532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69385773-69386273 Neighboring gene uncharacterized LOC124903516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69408482-69409456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69409457-69410430 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:69412000-69412925 Neighboring gene Sharpr-MPRA regulatory region 1691 Neighboring gene NANOG hESC enhancer GRCh37_chr15:69431124-69431625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69452636-69453136 Neighboring gene family with sequence similarity 47 member C pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6597 Neighboring gene glucuronic acid epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis. He X, et al. FASEB J, 2022 Dec. PMID 36421017
    2. LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis. Cui S, et al. Biochem Genet, 2021 Dec. PMID 33928467
    3. EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The "Double Stacking Effect". Tao SC, et al. Adv Biosyst, 2020 Sep. PMID 32803878
    4. Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer. Zhang R, et al. Eur Rev Med Pharmacol Sci, 2018 Oct. PMID 30402843
    5. LncRNA EWSAT1 promotes ovarian cancer progression through targeting miR-330-5p expression. Fu X, et al. Am J Transl Res, 2017. PMID 28979684, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis.
      Title: LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis.
    2. LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis.
      Title: LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis.
    3. EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The ""Double Stacking Effect"".
      Title: EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The "Double Stacking Effect".
    4. LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
      Title: LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
    5. Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer cells.
      Title: Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer.
    6. HPV-positive cervical neoplasia patients exhibit significantly reduced LINC01101 and LINC00277 expression levels.
      Title: LINC01101 and LINC00277 expression levels as novel factors in HPV-induced cervical neoplasia.
    7. Collectively, our data revealed that EWSAT1 promotes nasopharyngeal carcinoma cell growth in vitro through up-regulating cyclin D1 partially via 'spongeing' miR-326/330-5p clusters.
      Title: Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p.
    8. EWSAT1 promotes osteosarcoma cell growth and metastasis through suppression of MEG3 expression.
      Title: Long Noncoding RNA EWSAT1 Promotes Osteosarcoma Cell Growth and Metastasis Through Suppression of MEG3 Expression.
    9. data reveal that EWSAT1 is a downstream target of EWS-FLI1 that facilitates the development of Ewing sarcoma via the repression of target genes.
      Title: Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 277
    • testicular tissue protein Li 207
    • transmembrane protein 84

    Clone Names

    • FLJ33768, MGC126643, MGC126645

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026949.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA843716, AC027088, AK091087, BX493526
      Related
      ENST00000440444.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      69080850..69095824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      66903394..66918357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173610.1: Suppressed sequence

      Description
      NM_173610.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

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