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    MBNL1-AS1 MBNL1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 401093, updated on 10-Oct-2023

    Summary

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    Official Symbol
    MBNL1-AS1provided by HGNC
    Official Full Name
    MBNL1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:44584
    See related
    Ensembl:ENSG00000229619 AllianceGenome:HGNC:44584
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in urinary bladder (RPKM 5.2), endometrium (RPKM 5.1) and 23 other tissues See more
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    Genomic context

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    Location:
    3q25.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (152262616..152269626, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (155030515..155037526, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151980405..151987415, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20703 Neighboring gene long intergenic non-protein coding RNA 2917 Neighboring gene uncharacterized LOC101928166 Neighboring gene Sharpr-MPRA regulatory region 12239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20705 Neighboring gene NANOG hESC enhancer GRCh37_chr3:151978898-151979587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:151985921-151986763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:151986764-151987605 Neighboring gene muscleblind like splicing regulator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20708 Neighboring gene transmembrane protein 14E, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr3:152202190-152202395 Neighboring gene uncharacterized LOC105374163

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA MBNL1-AS1 Suppresses Cell Proliferation and Metastasis of Pancreatic Adenocarcinoma through Targeting Carcinogenic miR-301b-3p. Sulidankazha C, et al. Genet Res (Camb), 2023. PMID 36908851, Free PMC Article
    2. MBNL1-AS1 Promotes Hypoxia-Induced Myocardial Infarction via the miR-132-3p/RAB14/CAMTA1 Axis. Li Y, et al. Oxid Med Cell Longev, 2023. PMID 36785792, Free PMC Article
    3. LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-β pathway by modulating miR-424-5p/Smad7 axis. Su J, et al. Bioengineered, 2022 Mar. PMID 35311623, Free PMC Article
    4. Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling. Ding X, et al. Bioengineered, 2021 Dec. PMID 33648424, Free PMC Article
    5. LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer. Wei X, et al. Cancer Med, 2020 Jan. PMID 31769229, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MBNL1-AS1 attenuates tumor cell proliferation by regulating the miR-29c-3p/BVES signal in colorectal cancer.
      Title: MBNL1‑AS1 attenuates tumor cell proliferation by regulating the miR‑29c‑3p/BVES signal in colorectal cancer.
    2. LncRNA MBNL1-AS1 Suppresses Cell Proliferation and Metastasis of Pancreatic Adenocarcinoma through Targeting Carcinogenic miR-301b-3p.
      Title: LncRNA MBNL1-AS1 Suppresses Cell Proliferation and Metastasis of Pancreatic Adenocarcinoma through Targeting Carcinogenic miR-301b-3p.
    3. MBNL1-AS1 Promotes Hypoxia-Induced Myocardial Infarction via the miR-132-3p/RAB14/CAMTA1 Axis.
      Title: MBNL1-AS1 Promotes Hypoxia-Induced Myocardial Infarction via the miR-132-3p/RAB14/CAMTA1 Axis.
    4. The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers.
      Title: The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers.
    5. Tumour-suppressing functions of the lncRNA MBNL1-AS1/miR-889-3p/KLF9 axis in human breast cancer cells.
      Title: Tumour-suppressing functions of the lncRNA MBNL1-AS1/miR-889-3p/KLF9 axis in human breast cancer cells.
    6. LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-beta pathway by modulating miR-424-5p/Smad7 axis.
      Title: LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-β pathway by modulating miR-424-5p/Smad7 axis.
    7. Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
      Title: Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis.
    8. Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling.
      Title: Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling.
    9. LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
      Title: LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
    10. the present study suggests an inhibitory role of lncRNA MBNL1-AS1 in CSC drug resistance of Non-small cell lung cancer (NSCLC) by upregulating miR-301b-3p-targeted TGFBR2.
      Title: microRNA-301b-3p downregulation underlies a novel inhibitory role of long non-coding RNA MBNL1-AS1 in non-small cell lung cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Clone Names

    • FLJ79414

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027037.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, compared to variant 1.
      Source sequence(s)
      AA884826, AC106722, AK304857, BM790896

    2. NR_027038.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA884826, AC106722, AK316515, BM790896
      Related
      ENST00000608395.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      152262616..152269626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      155030515..155037526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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