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    LARGE-AS1 LARGE antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506195, updated on 10-Oct-2023

    Summary

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    Official Symbol
    LARGE-AS1provided by HGNC
    Official Full Name
    LARGE antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:40336
    See related
    Ensembl:ENSG00000224973 AllianceGenome:HGNC:40336
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 4.5) See more
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    Genomic context

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    See LARGE-AS1 in Genome Data Viewer
    Location:
    22q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (33724986..33750817)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (34182424..34208263)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (34120972..34146804)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene LARGE xylosyl- and glucuronyltransferase 1 Neighboring gene uncharacterized LOC105373007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13645 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:34018247-34018422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:34118270-34118798 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:34134097-34134616 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:34134617-34135136 Neighboring gene small nucleolar RNA, H/ACA box 50B Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:34175765-34176266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:34178675-34179175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13646 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:34231147-34231704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18886 Neighboring gene Sharpr-MPRA regulatory region 672 Neighboring gene Sharpr-MPRA regulatory region 8125 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:34245227-34245862 Neighboring gene H3K27ac hESC enhancers GRCh37_chr22:34249333-34249834 and GRCh37_chr22:34249835-34250334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:34265034-34265534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:34265535-34266035 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:34263445-34263944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:34271643-34272142 Neighboring gene Sharpr-MPRA regulatory region 329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:34294924-34295536 Neighboring gene Sharpr-MPRA regulatory region 1840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13648 Neighboring gene LARGE1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18888 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:34411551-34412114 Neighboring gene long intergenic non-protein coding RNA 1643 Neighboring gene uncharacterized LL22NC03-13G6.2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:34556235-34556992 Neighboring gene NANOG hESC enhancer GRCh37_chr22:34590594-34591168

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038949.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BC035866, BC043255, DB455410
      Related
      ENST00000438159.5

    2. NR_038950.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two internal exons, compared to variant 1.
      Source sequence(s)
      BC035866, DB455410
      Related
      ENST00000424291.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      33724986..33750817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      34182424..34208263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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