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    Zdhhc13 zinc finger DHHC-type palmitoyltransferase 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365252, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Zdhhc13provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 13provided by RGD
    Primary source
    RGD:1309736
    See related
    Ensembl:ENSRNOG00000014277 AllianceGenome:RGD:1309736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and protein palmitoylation. Predicted to be located in Golgi apparatus; Golgi-associated vesicle membrane; and endoplasmic reticulum. Predicted to be active in Golgi membrane. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 109.7), Spleen (RPKM 84.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc13 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (107623599..107662178)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (98487319..98525906)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (104106211..104145045)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member B3 like Neighboring gene MAS-related GPR, member B2 Neighboring gene cysteine and glycine rich protein 3 Neighboring gene E2F transcription factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. Goytain A, et al. J Biol Chem, 2008 Nov 28. PMID 18794299, Free PMC Article
    2. The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Lemonidis K, et al. Mol Biol Cell, 2014 Dec 1. PMID 25253725, Free PMC Article
    3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156470

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC13
    Names
    probable palmitoyltransferase ZDHHC13
    zinc finger, DHHC domain containing 13
    zinc finger, DHHC-type containing 13
    NP_001382044.1
    XP_038940918.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395115.1 → NP_001382044.1  palmitoyltransferase ZDHHC13

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JBF2, E9PU37
      Related
      ENSRNOP00000019175.4, ENSRNOT00000019175.6
      Conserved Domains (3) summary
      sd00045
      Location:81 → 112
      ANK; ANK repeat [structural motif]
      pfam01529
      Location:423 → 557
      DHHC; DHHC palmitoyltransferase
      cl39094
      Location:66 → 269
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      107623599..107662178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084990.2 → XP_038940918.1  palmitoyltransferase ZDHHC13 isoform X1

      Conserved Domains (3) summary
      COG0666
      Location:15 → 141
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:18 → 49
      ANK; ANK repeat [structural motif]
      pfam01529
      Location:293 → 427
      DHHC; DHHC palmitoyltransferase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039037.1: Suppressed sequence

      Description
      NM_001039037.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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