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    Myo7b myosin VIIb [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498834, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Myo7bprovided by RGD
    Official Full Name
    myosin VIIbprovided by RGD
    Primary source
    RGD:1561153
    See related
    Ensembl:ENSRNOG00000015035 AllianceGenome:RGD:1561153
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561153
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including brush border assembly; sensory perception of sound; and vesicle transport along actin filament. Predicted to be located in apical cytoplasm and brush border. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Orthologous to human MYO7B (myosin VIIB). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 73.0), Liver (RPKM 21.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo7b in Genome Data Viewer
    Location:
    18p12
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23862533..23944081, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23588307..23669841, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24742329..24823889, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 33 Neighboring gene SFT2 domain containing 3 Neighboring gene uncharacterized LOC120098222 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene G protein-coupled receptor 17 Neighboring gene uncharacterized LOC134482980 Neighboring gene interacts with SUPT6H, CTD assembly factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Crawley SW, et al. Cell, 2014 Apr 10. PMID 24725409, Free PMC Article
    2. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-VIIb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191941.1 → NP_001178870.1  unconventional myosin-VIIb

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZSV6, F1M885
      Related
      ENSRNOP00000021405.6, ENSRNOT00000021405.8
      Conserved Domains (10) summary
      smart00015
      Location:787 → 809
      IQ; Calmodulin-binding motif
      smart00139
      Location:1646 → 1793
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:60 → 761
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1802 → 2014
      B41; Band 4.1 homologues
      cd13198
      Location:1408 → 1504
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:2010 → 2105
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:1304 → 1405
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:79 → 750
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:1912 → 2014
      FERM_M; FERM central domain
      cl17036
      Location:1505 → 1565
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      23862533..23944081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254600.5 → XP_006254662.1  unconventional myosin-VIIb isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3A7, A0A8I5ZSV6
      Related
      ENSRNOP00000072561.1
      Conserved Domains (10) summary
      smart00015
      Location:787 → 809
      IQ; Calmodulin-binding motif
      smart00139
      Location:1646 → 1793
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:60 → 761
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1802 → 2014
      B41; Band 4.1 homologues
      cd13198
      Location:1408 → 1504
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:2010 → 2105
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:1304 → 1405
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:79 → 750
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:1912 → 2014
      FERM_M; FERM central domain
      cl17036
      Location:1505 → 1565
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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