Ptbp3 polypyrimidine tract binding protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptbp3provided by RGD
Official Full Name: polypyrimidine tract binding protein 3provided by RGD
Primary source: RGD:621671
See related: Ensembl:ENSRNOG00000016334 AllianceGenome:RGD:621671
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rod1
Summary: Predicted to enable mRNA binding activity. Involved in regulation of cell differentiation. Predicted to be active in nucleus. Orthologous to human PTBP3 (polypyrimidine tract binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 502.1), Thymus (RPKM 470.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (79108376..79194533, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (74313367..74399439, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (76670074..76756196, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polypyrimidine tract-binding protein 3

Names: ROD1 regulator of differentiation 1; regulator of differentiation (in S. pombe) 1; regulator of differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031346.3 → NP_112636.1 polypyrimidine tract-binding protein 3

See identical proteins and their annotated locations for NP_112636.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9Z118

UniProtKB/TrEMBL

A0A8L2UJS5

Related

ENSRNOP00000069354.2, ENSRNOT00000089251.2

Conserved Domains (1) summary

TIGR01649
Location:28 → 523

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

79108376..79194533 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110848.2 → XP_038966776.1 polypyrimidine tract-binding protein 3 isoform X4

UniProtKB/TrEMBL

A0A8I6AIH3, A6KDW6

Related

ENSRNOP00000092713.1

Conserved Domains (1) summary

TIGR01649
Location:1 → 457

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
XM_006238207.5 → XP_006238269.3 polypyrimidine tract-binding protein 3 isoform X2
XM_006238206.5 → XP_006238268.3 polypyrimidine tract-binding protein 3 isoform X1
XM_063288481.1 → XP_063144551.1 polypyrimidine tract-binding protein 3 isoform X3