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    Tigit T cell immunoreceptor with Ig and ITIM domains [ Mus musculus (house mouse) ]

    Gene ID: 100043314, updated on 27-May-2024

    Summary

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    Official Symbol
    Tigitprovided by MGI
    Official Full Name
    T cell immunoreceptor with Ig and ITIM domainsprovided by MGI
    Primary source
    MGI:MGI:3642260
    See related
    Ensembl:ENSMUSG00000071552 AllianceGenome:MGI:3642260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vstm3
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 1.9), small intestine adult (RPKM 1.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tigit in Genome Data Viewer
    Location:
    16 B4; 16 28.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43469224..43485494, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43626137..43665125, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_40880 Neighboring gene predicted gene 15713 Neighboring gene STARR-seq mESC enhancer starr_40881 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43507109-43507410 Neighboring gene STARR-seq mESC enhancer starr_40882 Neighboring gene STARR-seq mESC enhancer starr_40883 Neighboring gene STARR-seq mESC enhancer starr_40885 Neighboring gene STARR-positive B cell enhancer ABC_E7450 Neighboring gene STARR-positive B cell enhancer ABC_E4170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:43690256-43690365 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43698828-43699128 Neighboring gene STARR-seq mESC enhancer starr_40886 Neighboring gene STARR-positive B cell enhancer ABC_E1923 Neighboring gene microRNA 568 Neighboring gene predicted gene, 53956 Neighboring gene STARR-seq mESC enhancer starr_40887 Neighboring gene dopamine receptor D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Studying TIGIT activity against tumors through the generation of knockout mice. Rishiq A, et al. Oncoimmunology, 2023. PMID 37261087, Free PMC Article
    2. Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis. Gao Y, et al. PLoS Pathog, 2023 Mar. PMID 36930687, Free PMC Article
    3. TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A-Producing CD4(+) Tissue-Resident Memory T Cells. Chen B, et al. Front Immunol, 2022. PMID 35844584, Free PMC Article
    4. TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy. Zhang W, et al. JCI Insight, 2021 Jun 8. PMID 34100383, Free PMC Article
    5. Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection. Aldridge DL, et al. Immunohorizons, 2021 Jun 4. PMID 34088852

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIGIT regulates CD4[+] T cell immunity against polymicrobial sepsis.
      Title: TIGIT regulates CD4(+) T cell immunity against polymicrobial sepsis.
    2. TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes.
      Title: TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes.
    3. Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies.
      Title: Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies.
    4. IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.
      Title: IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.
    5. Dynamic changes in TIGIT expression on the T-cell surface and TIGIT-mediated T-cell dysfunction in the brains of mice with chronic Toxoplasma gondii infection.
      Title: Dynamic changes in TIGIT expression on the T-cell surface and TIGIT-mediated T-cell dysfunction in the brains of mice with chronic Toxoplasma gondii infection.
    6. [The number of TIGIT[+]CD8[+] T cells increases but their cytokine secretion decreases in the lungs of Plasmodium yoelii infected mice].
      Title: [The number of TIGIT(+)CD8(+) T cells increases but their cytokine secretion decreases in the lungs of Plasmodium yoelii infected mice].
    7. Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
      Title: Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
    8. Studying TIGIT activity against tumors through the generation of knockout mice.
      Title: Studying TIGIT activity against tumors through the generation of knockout mice.
    9. TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy.
      Title: TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy.
    10. Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis.
      Title: Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-12 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-10 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell immunoreceptor with Ig and ITIM domains
    Names
    V-set and transmembrane domain containing 3
    V-set and transmembrane domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146325.2 → NP_001139797.1  T-cell immunoreceptor with Ig and ITIM domains precursor

      See identical proteins and their annotated locations for NP_001139797.1

      Status: VALIDATED

      Source sequence(s)
      AC120871, AC154408
      Consensus CDS
      CCDS49852.1
      UniProtKB/Swiss-Prot
      P86176
      UniProtKB/TrEMBL
      A0A0B4J1G6
      Related
      ENSMUSP00000093770.5, ENSMUST00000096065.6
      Conserved Domains (2) summary
      smart00410
      Location:32 → 127
      IG_like; Immunoglobulin like
      cl11960
      Location:40 → 128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43469224..43485494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316834.3 → XP_017172323.1  T-cell immunoreceptor with Ig and ITIM domains isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:40 → 128
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86176.1 GenPept UniProtKB/Swiss-Prot:P86176

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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