GPX8 glutathione peroxidase 8 (putative) [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPX8provided by HGNC
Official Full Name: glutathione peroxidase 8 (putative)provided by HGNC
Primary source: HGNC:HGNC:33100
See related: Ensembl:ENSG00000164294 MIM:617172; AllianceGenome:HGNC:33100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPx-8; UNQ847; EPLA847; GSHPx-8
Summary: Enables peroxidase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta (RPKM 14.8), endometrium (RPKM 12.4) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q11.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (55160171..55167297)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (55987458..55994584)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (54455999..54463125)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPX8[+] cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment.
Title: GPX8(+) cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment.
GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses.
Title: GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses.
GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells.
Title: GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells.
GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma.
Title: GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma.
GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway.
Title: GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway.
GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer.
Title: GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer.
Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
Title: Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data.
Title: Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data.
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Title: The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Study provides evidence that the conserved N-terminal transmembrane domain of GPX8, in addition to its enzymatic activity, is essential for regulating Ca(2+) dynamics revealing a novel level of integration between redox-related proteins and Ca(2+) signaling/homeostasis.
Title: Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N33071 (e-PCR)
- UniSTS:30486

STS-N22158 (e-PCR)
- UniSTS:68960

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	EXP Inferred from Experiment more info	PubMed
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable glutathione peroxidase 8

NP_001008398.2

EC 1.11.1.9

NP_001293126.1

EC 1.11.1.9

NP_001293127.1

EC 1.11.1.9

NP_001293130.1

EC 1.11.1.9

XP_006714694.1

EC 1.11.1.9

XP_054208642.1

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008397.4 → NP_001008398.2 probable glutathione peroxidase 8 isoform a

See identical proteins and their annotated locations for NP_001008398.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK074216, BM988796, BX537894, BX647770, CN390753

Consensus CDS

CCDS34156.1

UniProtKB/Swiss-Prot

Q8TED1

Related

ENSP00000423822.1, ENST00000503787.6

Conserved Domains (1) summary

TIGR02540
Location:46 → 198

gpx7; putative glutathione peroxidase Gpx7
NM_001306197.2 → NP_001293126.1 probable glutathione peroxidase 8 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' terminal exon, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AK298545, BM988796, BX537894, BX647770, CN390753

Consensus CDS

CCDS78009.1

UniProtKB/TrEMBL

E7ETY7

Related

ENSP00000427466.1, ENST00000515370.1

Conserved Domains (1) summary

cl00388
Location:15 → 147

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_001306198.2 → NP_001293127.1 probable glutathione peroxidase 8 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK074216, AK307365, BM988796, BX537894, BX647770, CN390753

Consensus CDS

CCDS82997.1

UniProtKB/TrEMBL

J3KNB5

Related

ENSP00000296734.6, ENST00000296734.6

Conserved Domains (1) summary

cl00388
Location:46 → 69

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_001306201.2 → NP_001293130.1 probable glutathione peroxidase 8 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in both the 5' terminal exon and in an internal exon, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.

Source sequence(s)

AK074216, BM988796, BX537894, BX647770, CN390753, DA660205

UniProtKB/Swiss-Prot

Q8TED1

Conserved Domains (1) summary

cl00388
Location:14 → 105

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

NR_131336.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) splices out an alternate segment in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BM988796, BX537894, BX647770, CN390753

Related

ENST00000506123.5
NR_131337.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) splices out an alternate segment in the 5' terminal exon, and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BM835879, BM988796, BX537894, BX647770, CN390753
NR_131338.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) splices out an alternate segment in the 5' terminal exon, and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK074216, BM988796, BX537894, BX647770, CN390753, HY174481
NR_131340.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK074216, BG620710, BM988796, BX537894, BX647770, CN390753

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

55160171..55167297

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006714631.3 → XP_006714694.1 probable glutathione peroxidase 8 isoform X1

Conserved Domains (1) summary

TIGR02540
Location:46 → 199

gpx7; putative glutathione peroxidase Gpx7