pyya peptide YYa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pyyaprovided by ZNC
Official Full Name: peptide YYaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-71
See related: Ensembl:ENSDARG00000053449 AllianceGenome:ZFIN:ZDB-GENE-980526-71
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pyy; zgc:194161; zgc:194175
Summary: Enables type 2 neuropeptide Y receptor binding activity. Predicted to be involved in feeding behavior and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to several human genes including PYY (peptide YY). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (33340939..33344780)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (33209225..33213066)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties
Title: Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.
Developmental expression of zYb and zYc receptors suggests a role for peptide YY (PYY) in organogenesis.
Title: Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish.

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General gene information

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Markers

fj37b04.y1 (e-PCR)
- UniSTS:199228

pyy (e-PCR), detects polymorphism
- UniSTS:238239

pyy (e-PCR), detects polymorphism
- UniSTS:205525

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide Y receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 2 neuropeptide Y receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 neuropeptide Y receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptide YY-A

Names: peptide YY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164371.1 → NP_001157843.1 peptide YY-A precursor

See identical proteins and their annotated locations for NP_001157843.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

CABZ01012959, EH440265

UniProtKB/Swiss-Prot

B3DGK4, Q9I8P2

Related

ENSDARP00000108040.2, ENSDART00000128786.3

Conserved Domains (1) summary

pfam00159
Location:30 → 64

Hormone_3; Pancreatic hormone peptide
NM_131016.2 → NP_571091.1 peptide YY-A precursor

See identical proteins and their annotated locations for NP_571091.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC162436, CABZ01012959, EH440265

UniProtKB/Swiss-Prot

B3DGK4, Q9I8P2

Related

ENSDARP00000152843.1, ENSDART00000186352.1

Conserved Domains (1) summary

pfam00159
Location:30 → 64

Hormone_3; Pancreatic hormone peptide