tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnfaip1provided by ZNC
Official Full Name: tumor necrosis factor, alpha-induced protein 1 (endothelial)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5610
See related: Ensembl:ENSDARG00000041565 AllianceGenome:ZFIN:ZDB-GENE-030131-5610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55302; wu:fi06b02
Summary: Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within protein homooligomerization. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (20529222..20541185)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (20593495..20605453)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development.
Title: CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199799.1 → NP_956093.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

See identical proteins and their annotated locations for NP_956093.1

Status: PROVISIONAL

Source sequence(s)

BC044362

UniProtKB/TrEMBL

Q7ZYX6

Related

ENSDARP00000060934.6, ENSDART00000060935.8

Conserved Domains (2) summary

smart00225
Location:41 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

cl02518
Location:42 → 132

BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

20529222..20541185

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157506.4 → XP_005157563.1 BTB/POZ domain-containing protein TNFAIP1 isoform X1

See identical proteins and their annotated locations for XP_005157563.1

UniProtKB/TrEMBL

A0A8M6Z2V0, F1R5K5

Conserved Domains (1) summary

cl02518
Location:42 → 132

BTB; BTB/POZ domain
XM_021481342.1 → XP_021337017.1 BTB/POZ domain-containing protein TNFAIP1 isoform X1

UniProtKB/TrEMBL

A0A8M6Z2V0, F1R5K5

Conserved Domains (1) summary

cl02518
Location:42 → 132

BTB; BTB/POZ domain
XM_017359218.2 → XP_017214707.1 BTB/POZ domain-containing protein TNFAIP1 isoform X1

UniProtKB/TrEMBL

A0A8M6Z2V0, F1R5K5

Related

ENSDARP00000153764.1, ENSDART00000186312.1

Conserved Domains (1) summary

cl02518
Location:42 → 132

BTB; BTB/POZ domain