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    sulf2b sulfatase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 322056, updated on 30-May-2024

    Summary

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    Official Symbol
    sulf2bprovided by ZNC
    Official Full Name
    sulfatase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-775
    See related
    Ensembl:ENSDARG00000013838 AllianceGenome:ZFIN:ZDB-GENE-030131-775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SULF2; sulf2l; wu:fb48e04; si:dkeyp-84g9.1
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of with a positive effect on epithelial structure maintenance. Predicted to be located in Golgi stack and extracellular space. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; head; neural rod; segmental plate; and somite. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See sulf2b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (15203819..15563523, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (15447742..15807504, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20, b Neighboring gene Rho GTPase activating protein 46b Neighboring gene uncharacterized LOC100034569 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene MRG/MORF4L binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2. Gorsi B, et al. Dev Dyn, 2010 Dec. PMID 20981828
    2. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Danesin C, et al. Sci Rep, 2021 Jan 8. PMID 33420239, Free PMC Article
    3. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Schenk H, et al. Biomed Res Int, 2019. PMID 31428635, Free PMC Article
    4. Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development. Xu J, et al. Genetics, 2006 Oct. PMID 16888327, Free PMC Article
    5. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish sulf1 and sulf2a are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle.
      Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylsulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_positive_effect epithelial structure maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in esophagus smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innervation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    extracellular sulfatase Sulf-2; extracellular sulfatase Sulf-2b
    Names
    sulf2a
    sulfatase 2, like
    sulfatase FP2a
    sulfatase FP2b
    XP_009294984.2
    XP_009294986.2
    XP_017208998.1
    XP_017208999.1
    XP_017209000.1
    XP_021325409.1
    XP_021325410.1
    XP_021325411.1
    XP_021325412.1
    XP_021325413.1
    XP_021325414.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003833.3 → NP_001003833.3  extracellular sulfatase Sulf-2b precursor

      Status: VALIDATED

      Source sequence(s)
      BX537335, CR759764
      Related
      ENSDARP00000036209.5, ENSDART00000035865.7

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      15203819..15563523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353510.2 → XP_017208999.1  extracellular sulfatase Sulf-2 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YXM3
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    2. XM_017353511.2 → XP_017209000.1  extracellular sulfatase Sulf-2 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YXM3
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_017353509.1 → XP_017208998.1  extracellular sulfatase Sulf-2 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YXM3
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    4. XM_021469735.1 → XP_021325410.1  extracellular sulfatase Sulf-2 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YXM3
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    5. XM_021469737.1 → XP_021325412.1  extracellular sulfatase Sulf-2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9P505
      Related
      ENSDARP00000121392.1, ENSDART00000139135.2
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    6. XM_021469738.1 → XP_021325413.1  extracellular sulfatase Sulf-2 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PKK6
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    7. XM_021469739.1 → XP_021325414.1  extracellular sulfatase Sulf-2 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PKK6
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    8. XM_021469736.1 → XP_021325411.1  extracellular sulfatase Sulf-2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PSW4
      Conserved Domains (3) summary
      cd16147
      Location:45 → 387
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:551 → 676
      DUF3740; Sulfatase protein
      cl23718
      Location:764 → 813
      ALP_like; alkaline phosphatases and sulfatases

    9. XM_009296709.3 → XP_009294984.2  extracellular sulfatase Sulf-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B5Z5
      Conserved Domains (1) summary
      cl28058
      Location:405 → 1032
      DNA_pol_B_2; DNA polymerase type B, organellar and viral

    10. XM_021469734.1 → XP_021325409.1  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKK2
      Conserved Domains (1) summary
      cl28058
      Location:519 → 1146
      DNA_pol_B_2; DNA polymerase type B, organellar and viral

    11. XM_009296711.3 → XP_009294986.2  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKK2
      Conserved Domains (1) summary
      cl28058
      Location:519 → 1146
      DNA_pol_B_2; DNA polymerase type B, organellar and viral

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395137.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      222009..307373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395359.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      234844..304976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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