eif4ebp3l eukaryotic translation initiation factor 4E binding protein 3, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif4ebp3lprovided by ZNC
Official Full Name: eukaryotic translation initiation factor 4E binding protein 3, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-26
See related: Ensembl:ENSDARG00000041607 AllianceGenome:ZFIN:ZDB-GENE-030826-26
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: 4E-BP; cb750; 4E-BP3; eif4ebp3; zgc:56330; wu:fc30g07
Summary: Predicted to enable eukaryotic initiation factor 4E binding activity. Acts upstream of or within regulation of muscle hypertrophy. Predicted to be active in cytoplasm. Is expressed in several structures, including anterior neural keel; digestive system; immature eye; nervous system; and tail bud. Orthologous to human EIF4EBP3 (eukaryotic translation initiation factor 4E binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (6972868..6987589, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (6666141..6680901, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By selectively inhibiting translational initiation of mef2ca and other mRNAs, eIF4EBP3L reprograms the translational profile of muscle, enabling it to adjust to new environmental conditions.
Title: eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.

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General gene information

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Markers

fc12a04.x1 (e-PCR)
- UniSTS:192544

fc12a04.x1 (e-PCR)
- UniSTS:192545

fc30g07.x1 (e-PCR)
- UniSTS:187944

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic initiation factor 4E binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E-binding protein 3-like

Names: eIF4E-1A-binding protein; eIF4E-binding protein 3; eukaryotic translation initiation factor 4E-1A-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199683.1 → NP_955977.1 eukaryotic translation initiation factor 4E-binding protein 3-like

See identical proteins and their annotated locations for NP_955977.1

Status: PROVISIONAL

Source sequence(s)

BC046079

UniProtKB/Swiss-Prot

Q98TT6

Related

ENSDARP00000060989.3, ENSDART00000060990.5

Conserved Domains (1) summary

pfam05456
Location:9 → 112

eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)