timm50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: timm50provided by ZNC
Official Full Name: translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1618
See related: Ensembl:ENSDARG00000031098 AllianceGenome:ZFIN:ZDB-GENE-040426-1618
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66357
Summary: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Acts upstream of or within apoptotic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in several structures, including immature eye; margin; midbrain; pectoral fin musculature; and segmental plate. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (20475694..20528494, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (20539962..20592762, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit TIM50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200665.2 → NP_956959.1 mitochondrial import inner membrane translocase subunit TIM50 precursor

See identical proteins and their annotated locations for NP_956959.1

Status: PROVISIONAL

Source sequence(s)

BC057522

UniProtKB/Swiss-Prot

Q6NWD4, Q6PFK0

UniProtKB/TrEMBL

B2GQE9

Related

ENSDARP00000048422.7, ENSDART00000048423.8

Conserved Domains (1) summary

pfam03031
Location:183 → 330

NIF; NLI interacting factor-like phosphatase