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    nsun4 NOP2/Sun RNA methyltransferase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 494106, updated on 19-Jun-2024

    Summary

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    Official Symbol
    nsun4provided by ZNC
    Official Full Name
    NOP2/Sun RNA methyltransferase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-77
    See related
    Ensembl:ENSDARG00000021324 AllianceGenome:ZFIN:ZDB-GENE-041212-77
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101708; CH73-222E2.2
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to act upstream of or within methylation. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nsun4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (10160484..10169433)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (10362664..10371859)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene alpha-2-HS-glycoprotein 2 Neighboring gene profilin 2a Neighboring gene diencephalon/mesencephalon homeobox 1a Neighboring gene growth arrest and DNA-damage-inducible, alpha, a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Towards the understanding of the cocoa transcriptome: Production and analysis of an exhaustive dataset of ESTs of Theobroma cacao L. generated from various tissues and under various conditions. Argout X, et al. BMC Genomics, 2008 Oct 30. PMID 18973681, Free PMC Article
    2. Distinct requirements for Wntless in habenular development. Kuan YS, et al. Dev Biol, 2015 Oct 15. PMID 26116173, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5-methylcytosine rRNA methyltransferase NSUN4
    Names
    NOL1/NOP2/Sun domain family, member 4
    NP_001008649.1
    XP_021335728.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008649.1 → NP_001008649.1  5-methylcytosine rRNA methyltransferase NSUN4

      See identical proteins and their annotated locations for NP_001008649.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086725
      UniProtKB/TrEMBL
      Q5PRB6
      Conserved Domains (1) summary
      cl17173
      Location:109 → 269
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      10160484..10169433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480053.1 → XP_021335728.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q8A2
      Related
      ENSDARP00000115280.1, ENSDART00000136018.2
      Conserved Domains (1) summary
      cl25484
      Location:164 → 335
      Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF
    Nucleotide Protein
    Heading Accession and Version

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