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    picalmb phosphatidylinositol binding clathrin assembly protein b [ Danio rerio (zebrafish) ]

    Gene ID: 445286, updated on 27-Mar-2024

    Summary

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    Official Symbol
    picalmbprovided by ZNC
    Official Full Name
    phosphatidylinositol binding clathrin assembly protein bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6795
    See related
    Ensembl:ENSDARG00000014137 AllianceGenome:ZFIN:ZDB-GENE-030131-6795
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    picalm; fa01d03; picalml; zgc:91993; wu:fa01d03; wu:fa05d03; wu:fb69g01; wu:fe17e02
    Summary
    Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within clathrin coat assembly. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See picalmb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (19727987..19772463, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (19792255..19836663, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:dkey-4p15.5 Neighboring gene synaptotagmin-like 2b Neighboring gene si:ch211-229d2.5 Neighboring gene zona pellucida-like domain containing 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol binding clathrin assembly protein b
    Names
    phosphatidylinositol binding clathrin assembly protein, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003741.1 → NP_001003741.1  phosphatidylinositol binding clathrin assembly protein b

      See identical proteins and their annotated locations for NP_001003741.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079523
      UniProtKB/TrEMBL
      A0A0R4IFT4, A0A8M1N1S6, F1R5M0, Q6AXI5
      Related
      ENSDARP00000131752.2, ENSDART00000159475.2
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain
      pfam08287
      Location:265 → 344
      DASH_Spc19; Spc19

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      19727987..19772463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017359233.2 → XP_017214722.1  phosphatidylinositol binding clathrin assembly protein b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z9M1

    2. XM_017359234.2 → XP_017214723.1  phosphatidylinositol binding clathrin assembly protein b isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z2V9

    3. XM_009291638.3 → XP_009289913.1  phosphatidylinositol binding clathrin assembly protein b isoform X8

      UniProtKB/TrEMBL
      A0A8M3AIG6
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain
      pfam08287
      Location:278 → 349
      DASH_Spc19; Spc19

    4. XM_009291636.3 → XP_009289911.1  phosphatidylinositol binding clathrin assembly protein b isoform X4

      UniProtKB/TrEMBL
      A0A8M3AHB8
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain

    5. XM_009291635.3 → XP_009289910.1  phosphatidylinositol binding clathrin assembly protein b isoform X2

      UniProtKB/TrEMBL
      A0A8M3APR9
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain

    6. XM_009291639.3 → XP_009289914.1  phosphatidylinositol binding clathrin assembly protein b isoform X9

      UniProtKB/TrEMBL
      A0A8M3ASP1
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain
      pfam08287
      Location:278 → 349
      DASH_Spc19; Spc19

    7. XM_017359236.2 → XP_017214725.1  phosphatidylinositol binding clathrin assembly protein b isoform X6

      UniProtKB/TrEMBL
      A0A8M6ZA05

    8. XM_009291640.3 → XP_009289915.1  phosphatidylinositol binding clathrin assembly protein b isoform X10

      UniProtKB/TrEMBL
      A0A8M3APS6
      Related
      ENSDARP00000144339.2, ENSDART00000175502.2
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain
      pfam08287
      Location:278 → 349
      DASH_Spc19; Spc19

    9. XM_009291637.3 → XP_009289912.1  phosphatidylinositol binding clathrin assembly protein b isoform X7

      UniProtKB/TrEMBL
      A0A8M3B104
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain

    10. XM_009291641.3 → XP_009289916.1  phosphatidylinositol binding clathrin assembly protein b isoform X11

      UniProtKB/TrEMBL
      A0A8M3AHC4
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain
      pfam08287
      Location:278 → 349
      DASH_Spc19; Spc19

    11. XM_009291643.3 → XP_009289918.1  phosphatidylinositol binding clathrin assembly protein b isoform X13

      UniProtKB/TrEMBL
      A0A8M3AIH0
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain
      pfam08287
      Location:265 → 344
      DASH_Spc19; Spc19

    12. XM_009291642.3 → XP_009289917.1  phosphatidylinositol binding clathrin assembly protein b isoform X12

      UniProtKB/TrEMBL
      A0A8M3B110
      Conserved Domains (2) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain
      pfam08287
      Location:265 → 344
      DASH_Spc19; Spc19

    13. XM_017359235.2 → XP_017214724.1  phosphatidylinositol binding clathrin assembly protein b isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z4D6
    Nucleotide Protein Strain
    Heading Accession and Version

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