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    mbpa myelin basic protein a [ Danio rerio (zebrafish) ]

    Gene ID: 326281, updated on 28-Apr-2024

    Summary

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    Official Symbol
    mbpaprovided by ZNC
    Official Full Name
    myelin basic protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030128-2
    See related
    Ensembl:ENSDARG00000036186 AllianceGenome:ZFIN:ZDB-GENE-030128-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mbp; cb274; fj33b11; wu:fj33b11; wu:fq15b02; zgc:136630
    Summary
    Predicted to be a structural constituent of myelin sheath. Located in myelin sheath and plasma membrane. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See mbpa in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (21814047..21832625, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (22229724..22248302, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 1 Neighboring gene zinc finger protein 516 Neighboring gene galanin receptor 1a Neighboring gene uncharacterized LOC110438149

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Bradley EC, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31529518, Free PMC Article
    2. Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber. Karttunen MJ, et al. PLoS One, 2017. PMID 28542521, Free PMC Article
    3. Cre-inducible site-specific recombination in zebrafish oligodendrocytes. Pinzon-Olejua A, et al. Dev Dyn, 2017 Jan. PMID 27666728
    4. A novel model of demyelination and remyelination in a GFP-transgenic zebrafish. Fang Y, et al. Biol Open, 2014 Dec 19. PMID 25527642, Free PMC Article
    5. Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Buckley CE, et al. Neuropharmacology, 2010 Sep. PMID 20450924

    See all (229) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes.
      Title: Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136630

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin basic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      21814047..21832625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002665561.2 → XP_002665607.1  myelin basic protein isoform X6

      UniProtKB/TrEMBL
      A0A8M1RMH8, F8W3W8
      Related
      ENSDARP00000124006.1, ENSDART00000148424.3
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 87
      Myelin_MBP; Myelin basic protein

    2. XM_005170082.1 → XP_005170139.1  myelin basic protein isoform X9

      UniProtKB/TrEMBL
      A0A8M2BHF5, F8W3A0
      Related
      ENSDARP00000124447.1, ENSDART00000150168.3
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 71
      Myelin_MBP; Myelin basic protein

    3. XM_005170081.1 → XP_005170138.1  myelin basic protein isoform X8

      See identical proteins and their annotated locations for XP_005170138.1

      UniProtKB/TrEMBL
      A0A8M2BHF0, Q5I2C7
      Related
      ENSDARP00000052555.6, ENSDART00000052556.8
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 79
      Myelin_MBP; Myelin basic protein

    4. XM_002665557.4 → XP_002665603.1  myelin basic protein isoform X3

      UniProtKB/TrEMBL
      A0A8M1RKW5, F8W3M5
      Related
      ENSDARP00000124357.2, ENSDART00000149259.4
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 120
      Myelin_MBP; Myelin basic protein

    5. XM_005170080.1 → XP_005170137.1  myelin basic protein isoform X7

      UniProtKB/TrEMBL
      A0A8M2BHV8, F8W2M5
      Related
      ENSDARP00000124675.1, ENSDART00000148797.3
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 83
      Myelin_MBP; Myelin basic protein

    6. XM_005170079.1 → XP_005170136.1  myelin basic protein isoform X5

      UniProtKB/TrEMBL
      A0A8M2BHF3, E7F0U0
      Related
      ENSDARP00000111439.2, ENSDART00000128196.4
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 91
      Myelin_MBP; Myelin basic protein

    7. XM_021468312.1 → XP_021323987.1  myelin basic protein isoform X2

      UniProtKB/TrEMBL
      A0A8M9P2C7
      Related
      ENSDARP00000124434.1, ENSDART00000149658.3
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 125
      Myelin_MBP; Myelin basic protein

    8. XM_002665562.3 → XP_002665608.1  myelin basic protein isoform X4

      UniProtKB/TrEMBL
      A0A8M1RHV8, F8W3V8
      Related
      ENSDARP00000124016.1, ENSDART00000149639.2
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 100
      Myelin_MBP; Myelin basic protein

    9. XM_001340280.4 → XP_001340316.2  myelin basic protein isoform X1

      UniProtKB/TrEMBL
      A0A8M1PZE1, I3ITP3
      Related
      ENSDARP00000126314.1, ENSDART00000151442.3
      Conserved Domains (1) summary
      pfam01669
      Location:1 → 132
      Myelin_MBP; Myelin basic protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001020483.1: Suppressed sequence

      Description
      NM_001020483.1: This RefSeq was temporarily suppressed because the CDS was partial when compared to available protein (homology) data.
    Nucleotide Protein
    Heading Accession and Version

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