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    Rsu1 Ras suppressor protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680419, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rsu1provided by RGD
    Official Full Name
    Ras suppressor protein 1provided by RGD
    Primary source
    RGD:1591781
    See related
    Ensembl:ENSRNOG00000017595 AllianceGenome:RGD:1591781
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of GTPase activity; positive regulation of cell-substrate adhesion; and signal transduction. Predicted to act upstream of or within Ras protein signal transduction and positive regulation of neural precursor cell proliferation. Predicted to be located in focal adhesion. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 185.8), Heart (RPKM 143.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81037848..81286127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76128774..76377515, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80388477..80577338, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348618 Neighboring gene phosphotriesterase related Neighboring gene uncharacterized LOC134482609 Neighboring gene complement C1q like 3 Neighboring gene uncharacterized LOC134482610 Neighboring gene cubilin Neighboring gene uncharacterized LOC102550536 Neighboring gene tRNA aspartic acid methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Cutler ML, et al. Mol Cell Biol, 1992 Sep. PMID 1508180, Free PMC Article
    2. The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading. Ito S, et al. Mol Biol Cell, 2010 Dec. PMID 20926685, Free PMC Article
    3. Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. Porcheri C, et al. J Neurosci, 2014 Apr 9. PMID 24719101, Free PMC Article
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras suppressor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109404.1 → NP_001102874.1  ras suppressor protein 1

      See identical proteins and their annotated locations for NP_001102874.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/TrEMBL
      A0A8I5ZQM5, A6JM38, D4A8F2
      Related
      ENSRNOP00000054637.5, ENSRNOT00000057827.5
      Conserved Domains (2) summary
      COG4886
      Location:38 → 202
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      81037848..81286127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276734.1 → XP_063132804.1  ras suppressor protein 1 isoform X2

    2. XM_063276735.1 → XP_063132805.1  ras suppressor protein 1 isoform X2

    3. XM_039096064.2 → XP_038951992.1  ras suppressor protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQM5
      Conserved Domains (2) summary
      COG4886
      Location:38 → 202
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_039096062.2 → XP_038951990.1  ras suppressor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQM5, A6JM38, D4A8F2
      Conserved Domains (2) summary
      COG4886
      Location:38 → 202
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_039096065.2 → XP_038951993.1  ras suppressor protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQM5
      Conserved Domains (2) summary
      COG4886
      Location:38 → 202
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    6. XM_039096066.2 → XP_038951994.1  ras suppressor protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZQM5
      Conserved Domains (2) summary
      COG4886
      Location:38 → 202
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. XR_005495332.2 RNA Sequence

    2. XR_010058931.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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