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    Bank1 B-cell scaffold protein with ankyrin repeats 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365948, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Bank1provided by RGD
    Official Full Name
    B-cell scaffold protein with ankyrin repeats 1provided by RGD
    Primary source
    RGD:1564639
    See related
    Ensembl:ENSRNOG00000032247 AllianceGenome:RGD:1564639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00104
    Summary
    Predicted to enable enzyme binding activity; signaling adaptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of B cell activation; negative regulation of protein kinase B signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to act upstream of or within negative regulation of gene expression; positive regulation of MAPK cascade; and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and systemic scleroderma (multiple). Orthologous to human BANK1 (B cell scaffold protein with ankyrin repeats 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 464.7), Lung (RPKM 129.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q43
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (227203998..227474008, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (224530475..224800420, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (241273763..241545527, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene solute carrier family 39 member 8 Neighboring gene ribosomal protein L29 like 8 Neighboring gene protein phosphatase 3 catalytic subunit alpha Neighboring gene uncharacterized LOC134485975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ankyrin-B p.S646F undergoes increased proteasome degradation and reduces cell viability in the H9c2 rat ventricular cardiomyoblast cell line. Chen L, et al. Biochem Cell Biol, 2020 Apr. PMID 31965814
    2. Association of BANK1 and cytokine gene polymorphisms with type 1 diabetes in Tunisia. Zouidi F, et al. Gene, 2014 Feb 25. PMID 24342660
    3. BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway. Wu YY, et al. J Immunol, 2013 Dec 15. PMID 24227780, Free PMC Article
    4. Genetic variants of BANK1 gene in autoimmune thyroid diseases: a case-control association study. Muhali FS, et al. Exp Clin Endocrinol Diabetes, 2013 Oct. PMID 24127308
    5. Association analysis of BANK1 gene with psoriasis in Southern Han Chinese. Zhang X, et al. Int J Immunogenet, 2011 Dec. PMID 21989138

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ankyrin-B p.S646F undergoes increased proteasome degradation and reduces cell viability in the H9c2 rat ventricular cardiomyoblast cell line.
      Title: Ankyrin-B p.S646F undergoes increased proteasome degradation and reduces cell viability in the H9c2 rat ventricular cardiomyoblast cell line.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell scaffold protein with ankyrin repeats

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047918.2 → NP_001041383.2  B-cell scaffold protein with ankyrin repeats

      See identical proteins and their annotated locations for NP_001041383.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZZK5, A6HVZ2
      Related
      ENSRNOP00000083548.1, ENSRNOT00000105974.1
      Conserved Domains (2) summary
      pfam14545
      Location:198 → 327
      DBB; Dof, BCAP, and BANK (DBB) motif,
      cl02529
      Location:344 → 396
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      227203998..227474008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591004.3 → XP_017446493.1  B-cell scaffold protein with ankyrin repeats isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZK5

    2. XM_039102804.2 → XP_038958732.1  B-cell scaffold protein with ankyrin repeats isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZK5, A0A8I6AIR4
      Related
      ENSRNOP00000092966.1
      Conserved Domains (2) summary
      pfam14545
      Location:198 → 326
      DBB; Dof, BCAP, and BANK (DBB) motif,
      pfam18567
      Location:28 → 153
      TIR_3; Toll/interleukin-1 receptor domain

    3. XM_039102806.2 → XP_038958734.1  B-cell scaffold protein with ankyrin repeats isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZK5
      Conserved Domains (2) summary
      pfam14545
      Location:198 → 326
      DBB; Dof, BCAP, and BANK (DBB) motif,
      pfam18567
      Location:28 → 153
      TIR_3; Toll/interleukin-1 receptor domain

    4. XM_039102807.2 → XP_038958735.1  B-cell scaffold protein with ankyrin repeats isoform X4

      UniProtKB/TrEMBL
      M0RAD7
      Related
      ENSRNOP00000066483.2
      Conserved Domains (2) summary
      pfam14545
      Location:182 → 310
      DBB; Dof, BCAP, and BANK (DBB) motif,
      pfam18567
      Location:12 → 137
      TIR_3; Toll/interleukin-1 receptor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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