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    Pabpn1 poly(A) binding protein, nuclear 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116697, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Pabpn1provided by RGD
    Official Full Name
    poly(A) binding protein, nuclear 1provided by RGD
    Primary source
    RGD:619928
    See related
    Ensembl:ENSRNOG00000042195 AllianceGenome:RGD:619928
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; poly(A)+ mRNA export from nucleus; and positive regulation of polynucleotide adenylyltransferase activity. Located in nuclear inclusion body. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 80.0), Testes (RPKM 78.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pabpn1 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32337955..32342700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28368100..28372712)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33555640..33560251)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene Bcl2-like 2 Neighboring gene solute carrier family 22, member 17 Neighboring gene embryonal Fyn-associated substrate

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear compartmentalization and dynamics of the poly(A)-binding protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under physiological and osmotic stress conditions. Villagra NT, et al. Mol Cell Neurosci, 2008 Mar. PMID 18255312
    2. Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene. Matsubara S, et al. Neuromuscul Disord, 2016 Jul. PMID 27209344
    3. Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus. Berciano MT, et al. Hum Mol Genet, 2004 Apr 15. PMID 14976164
    4. Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells. Zhang L, et al. J Cell Mol Med, 2022 Sep. PMID 35894779, Free PMC Article
    5. Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1. Su YL, et al. PLoS One, 2012. PMID 22844456, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
      Title: Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135008.1 → NP_001128480.1  polyadenylate-binding protein 2

      See identical proteins and their annotated locations for NP_001128480.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KGX0, G3V7Z8
      Related
      ENSRNOP00000021096.3, ENSRNOT00000021096.7
      Conserved Domains (2) summary
      COG0724
      Location:109 → 285
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:169 → 244
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32337955..32342700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273914.1 → XP_063129984.1  polyadenylate-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5F1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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