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    Sec24c SEC24 homolog C, COPII coat complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685144, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sec24cprovided by RGD
    Official Full Name
    SEC24 homolog C, COPII coat complex componentprovided by RGD
    Primary source
    RGD:1597739
    See related
    Ensembl:ENSRNOG00000009042 AllianceGenome:RGD:1597739
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 180.5), Liver (RPKM 167.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sec24c in Genome Data Viewer
    Location:
    15p16
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3651714..3674420, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3602460..3624524, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4035196..4057209, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene fucosyltransferase 11 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. Montgomery TR, et al. J Neurosci, 2014 Apr 30. PMID 24790205, Free PMC Article
    2. A family of mammalian proteins homologous to yeast Sec24p. Tang BL, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329445
    3. Mammalian COPII coat component SEC24C is required for embryonic development in mice. Adams EJ, et al. J Biol Chem, 2014 Jul 25. PMID 24876386, Free PMC Article
    4. Sec24 proteins and sorting at the endoplasmic reticulum. Pagano A, et al. J Biol Chem, 1999 Mar 19. PMID 10075675
    5. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. Bonnon C, et al. J Cell Sci, 2010 May 15. PMID 20427317

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Axonal delivery of serotonin transporter is contingent on recruitment of SEC24C in the endoplasmic reticulum.
      Title: Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec24C
    Names
    SEC24 family, member C
    SEC24 related gene family, member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109456.1 → NP_001102926.1  protein transport protein Sec24C

      See identical proteins and their annotated locations for NP_001102926.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474061
      UniProtKB/TrEMBL
      B5DEG8, F7ET87
      Related
      ENSRNOP00000012269.3, ENSRNOT00000012270.5
      Conserved Domains (7) summary
      COG5028
      Location:181 → 1091
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:500 → 759
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:962 → 1037
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:423 → 460
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:848 → 944
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:749 → 832
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      cl23807
      Location:143 → 233
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      3651714..3674420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093660.2 → XP_038949588.1  protein transport protein Sec24C isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZF0
      Related
      ENSRNOP00000071021.1
      Conserved Domains (2) summary
      PHA03247
      Location:7 → 269
      PHA03247; large tegument protein UL36; Provisional
      COG5028
      Location:181 → 1052
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

    2. XM_006251659.5 → XP_006251721.1  protein transport protein Sec24C isoform X3

      Conserved Domains (7) summary
      COG5028
      Location:181 → 1075
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:484 → 743
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:946 → 1021
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:407 → 444
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:832 → 928
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:733 → 816
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam11235
      Location:93 → 256
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    3. XM_006251656.5 → XP_006251718.1  protein transport protein Sec24C isoform X1

      See identical proteins and their annotated locations for XP_006251718.1

      UniProtKB/TrEMBL
      A0A0G2K626
      Related
      ENSRNOP00000073649.2
      Conserved Domains (2) summary
      PHA03247
      Location:7 → 343
      PHA03247; large tegument protein UL36; Provisional
      COG5028
      Location:181 → 1114
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

    4. XM_063274641.1 → XP_063130711.1  protein transport protein Sec24C isoform X2

      UniProtKB/TrEMBL
      B5DEG8, F7ET87

    5. XM_006251657.5 → XP_006251719.1  protein transport protein Sec24C isoform X1

      See identical proteins and their annotated locations for XP_006251719.1

      UniProtKB/TrEMBL
      A0A0G2K626
      Conserved Domains (2) summary
      PHA03247
      Location:7 → 343
      PHA03247; large tegument protein UL36; Provisional
      COG5028
      Location:181 → 1114
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

    6. XM_063274642.1 → XP_063130712.1  protein transport protein Sec24C isoform X2

      UniProtKB/TrEMBL
      B5DEG8, F7ET87

    7. XM_017599801.2 → XP_017455290.1  protein transport protein Sec24C isoform X2

      UniProtKB/TrEMBL
      B5DEG8, F7ET87
      Conserved Domains (7) summary
      COG5028
      Location:181 → 1091
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:500 → 759
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:962 → 1037
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:423 → 460
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:848 → 944
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:749 → 832
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      cl23807
      Location:143 → 233
      WWbp; WW-domain ligand protein

    8. XM_039093659.2 → XP_038949587.1  protein transport protein Sec24C isoform X1

      UniProtKB/TrEMBL
      A0A0G2K626
      Conserved Domains (2) summary
      PHA03247
      Location:7 → 343
      PHA03247; large tegument protein UL36; Provisional
      COG5028
      Location:181 → 1114
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    Nucleotide Protein Strain
    Heading Accession and Version

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